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Abstract Details

EEG and Seizure Characteristics of Adults with Neurocysticercosis-associated Epilepsy at the University Teaching Hospital in Lusaka, Zambia
Epilepsy/Clinical Neurophysiology (EEG)
P6 - Poster Session 6 (8:00 AM-9:00 AM)
1-005
To describe the electroclinical features of Neurocysticercosis-associated epilepsy and identify seizure severity predictors.
Neurocysticercosis (NCC), caused by the parasite taenia solium, is a neglected tropical disease and a leading cause of focal epilepsy in sub-Saharan Africa. Biomarkers to guide treatment and diagnosis of NCC-associated epilepsy are sparse.

A cross-sectional study of adults with NCC at UTH in Lusaka, Zambia was conducted. Data collected between December 2021 and March 2023 were analyzed.
Of 73 participants, 57 (78%) were male with mean age of 39.5+13.6 years. Most were either unemployed 22/66 (33%) or self/informally employed 30/66 (45%), and 22.6% (12/63) were people living with HIV. Clinical presentations comprised seizures (88.9%, 56/63), headache (12.7%, 8/63), cranial neuropathy (3.2%, 2/63) and incidental findings on CT head (3.2, 2/63). Of those with seizures (n=53), majority reportedly had either generalized (45.3%) or focal unaware seizures (45.3%). EEG was abnormal in 33% (21/63), of which 57.1% (12/21) showed focal abnormalities, and 41.7% (5/12) were epileptiform, with 11/21 (52.4%) being in those without seizures. Of 60 participants with neuroimaging, 44 (73.3%) had <10 lesions, 9 (15%) had 10-20 and 7 (11.7%) had >20. Stages of NCC lesions were 51.7% (31/60) vesicular, 41.2% (25/60) colloidal, 15% (9/60) granular nodular, 31.2% (19/60) calcified. Multiple stages were present in 38.3% (23/60). Mean Liverpool Seizure Severity Score was 56.5+8.8 (possible range, 20-80). Higher lesion number was not associated with abnormal EEG (p=0.42) nor higher seizure severity score (p=0.84). No association was found between NCC stage and presence of an abnormal EEG (p>0.05).
Disabling seizures were the commonest presentation of NCC. EEG and brain imaging findings were not predictive of seizure severity. Further investigation is needed into the association between NCC and abnormal EEG even in those without seizures, and the causes for male preponderance of NCC.
Authors/Disclosures
Melody T. Asukile, MBBS (University Teaching Hospital)
PRESENTER 		Dr. Asukile has received research support from Royal Society for Tropical Medicine and Hygiene. The institution of Dr. Asukile has received research support from Leverhulme Trust. Dr. Asukile has received personal compensation in the range of $0-$499 for serving as a meeting speaker with American Neurological Association.
Mashina Chomba, MBChB (University of Zambia) Dr. Chomba has nothing to disclose.
Mulenga Chilando (University Teaching Hospital) Mulenga Chilando has nothing to disclose.
Frighton B. Mutete, MBChB (Livingstone University Teaching Hospital) Dr. Mutete has nothing to disclose.
Chimuka Muleya No disclosure on file
Theresa Shankanga (University of Zambia, ridgeway campus) Miss Shankanga has nothing to disclose.
Diwell Mwansa (UNZA Ridgeway campus) Diwell Mwansa has nothing to disclose.
Ndonji Chiwaya, MD Ndonji Chiwaya has nothing to disclose.
Deanna Saylor, MD, MHS (Johns Hopkins Hospital) Dr. Saylor has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for 好色先生. The institution of Dr. Saylor has received research support from National Institutes of Health. The institution of Dr. Saylor has received research support from 好色先生. Dr. Saylor has a non-compensated relationship as a Member of multiple committees and task forces focused on improving access to MS medications to people across the world with Multiple Sclerosis International Federation that is relevant to AAN interests or activities. Dr. Saylor has a non-compensated relationship as a Member of the Neurology and COVID19 committee with World Health Organization that is relevant to AAN interests or activities. Dr. Saylor has a non-compensated relationship as a Member of the International Outreach Committee, Junior and Early Career Membership Committee, and 好色先生al Innovation Commitees with American Neurological Association that is relevant to AAN interests or activities.