Abstract Details

Title Multimodal Imaging Manifestations of Neuropsychiatric Involvement in Systemic Lupus Erythematosus

Topic Neurotoxicology

Presentation(s) S29 - (-)

Poster/Presentation
Number 004

Objective

Background The multimodal approach of using different conventional and non-conventional MRI techniques to better understand the pathogenesis of SLE is only in its infancy and more such studies are needed.

Design/Methods 26 SLE patients with diffuse NP syndromes (NPSLE) and 9 without CNS syndromes (non-NPSLE), and 36 age- and sex-matched healthy controls (HC) were scanned on a 3T MRI using a multimodal imaging approach. Patients with focal CNS involvement (stroke, seizure, etc.) were not included. Univariate and multivariate analyses were used to determine MRI- specific measure differences between SLE and HC and NPSLE and non-NPSLE groups for lesion burden, tissue-specific atrophy, magnetization transfer ratio (MTR) and diffusion-tensor imaging (DTI) outcomes.

Results In univariate analyses, SLE patients showed increased T1-lesion volume (LV, p<.0001), T2-LV (p<.002) and increased T1 lesion number (p<.0001) compared to HC. SLE patients showed decreased whole brain volume (p<.0001), gray matter volume (GM) (p<.0001), cortical volume (p<.0001), and increased lateral ventricle volume (p<.0001) and third ventricle width (p=.043) compared to HC. For MTR, only the NPSLE patients showed decreased normal appearing (NA) white matter (WM, p=.024) compared to HC. SLE patients had increased axial diffusivity (AD) of NAWM (p=.001), NA brain tissue (p=.016) and T2-LV (p=.019), and increased radial diffusivity (RD) of NAWM (p=.03) and of T2-LV (p=.042) compared to HC. In the multivariate regression analysis, decreased cortical volume was associated with SLE (R2 =0.54, p<.0001).

Conclusions This study suggests that cortical and central atrophy may be associated with NP and non-NP SLE patients. Severe microscopic tissue injury in the NAWM on AD and RD DTI measures in SLE patients indicates a predominant decrease of axonal density and myelin integrity.

Authors/Disclosures
Janet L. Shucard, PhD (Buffalo General Hospital) PRESENTER	No disclosure on file
David W. Shucard, PhD (State Univ of NY At Buffalo School of Medicine)	No disclosure on file
	No disclosure on file
Jackie Durfee (JNI - BNAC)	No disclosure on file
Jennifer L. Cox, PhD	Dr. Cox has nothing to disclose.
Niels Bergsland (Buffalo Neuroimaging Analysis Center / State University of New York At Buffalo)	Prof. Bergsland has nothing to disclose.
Michael G. Dwyer III, MD, PhD (Buffalo Neurological Analysis Center)	Dr. Dwyer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Dwyer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Keystone Heart, Ltd. Dr. Dwyer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novartis. The institution of Dr. Dwyer has received research support from Novartis. The institution of Dr. Dwyer has received research support from Keystone Heart, Ltd. The institution of Dr. Dwyer has received research support from Bristol Myers Squibb. The institution of Dr. Dwyer has received research support from Roche.
Ralph H. Benedict, PhD (University At Buffalo)	Dr. Benedict has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novartis. Dr. Benedict has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Roche. Dr. Benedict has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. Dr. Benedict has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Dr. Benedict has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Bristol Meyers Squibb. Dr. Benedict has received personal compensation in the range of $50,000-$99,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Benedict has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Biogen. Dr. Benedict has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Brystal Mier Squibb. Dr. Benedict has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for EMD Serono. The institution of Dr. Benedict has received research support from Genzyme. The institution of Dr. Benedict has received research support from Biogen. The institution of Dr. Benedict has received research support from Bristol Myer Squib. Dr. Benedict has received intellectual property interests from a discovery or technology relating to health care.
	No disclosure on file
Robert Zivadinov, MD, PhD, FAAN (Buffalo Neuroimaging Analysis Center)	The institution of Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BMS. The institution of Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Omnicuris. The institution of Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Myrobalan. Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Zivadinov has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for EMD Serono. Dr. Zivadinov has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Bristol Myers Squibb. The institution of Dr. Zivadinov has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen.
Olga Ciccarelli, MD, PhD, FRCP (UCL Institute of Neurology)	Prof. Ciccarelli has received personal compensation in the range of $0-$499 for serving as a Consultant for Lundebeck. Prof. Ciccarelli has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Prof. Ciccarelli has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Prof. Ciccarelli has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Merck. Prof. Ciccarelli has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for NEUROLOGY Journal.

��ɫ��

��ɫ��