Abstract Details

Title Altered Functional Brain Connectome in the Behavioral Variant of Frontotemporal Dementia

Topic Behavioral Neurology

Presentation(s) S54 - (-)

Poster/Presentation
Number 004

Objective

Background Topology-based analysis of the human brain networks offers a novel avenue for assessing the patterns of functional disconnection in neurodegenerative diseases.

Design/Methods Graph theoretical analysis was applied to resting state functional MRI (RS fMRI) data from 18 bvFTD patients and 50 healthy matched elderly individuals. Functional connectivity between 90 cortical and subcortical brain regions was estimated using bivariate correlation analysis and thresholded to construct a set of undirected graphs.

Results The global topological organization of the functional brain network in bvFTD patients was significantly disrupted as indicated by reduced small-world properties, reduced global efficiency and increased assortativity relative to normal elderly subjects. Compared with controls, bvFTD retained their major "hub" regions in the medial parietal, temporal and occipital lobes, but cortical hubs were not indicated in the frontal lobes. A decreased nodal centrality was also found in the left caudate nucleus, left insular cortices and some parts of the temporal lobes bilaterally. BvFTD patients showed the greatest decrease in inter-regional connectivity between the insular cortices and subcortical, temporal and frontal regions. Furthermore, in bvFTD patients, the alterations of various global network properties significantly correlated with executive function deficits.

Conclusions Our findings show that the global and local functional network is altered in bvFTD patients, suggesting a loss of efficiency in information exchange between both distant and close brain areas. The altered brain regions are mainly located in those structures that are closely associated with the neuropathological changes in bvFTD. It would appear that aberrant topology of the functional brain networks in bvFTD underlies cognitive deficits in these patients.

Authors/Disclosures
Massimo Filippi, MD, FAAN (Ospedale San Raffaele, Neuroimaging Research Unit) PRESENTER	Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.
Marinella Clerico, MD (University of Torino)	Dr. Clerico has nothing to disclose.
Federica Agosta (San Raffaele Scientific Institute)	Federica Agosta has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philips. Federica Agosta has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier INC.
	No disclosure on file
Paola Valsasina	No disclosure on file
	No disclosure on file
Elisa Canu (Ospedale San Raffaele)	The institution of Elisa Canu has received research support from Italian Ministry of Health .
Giuseppe Magnani	Giuseppe Magnani has nothing to disclose.
Stefano F. Cappa, MD	Dr. Cappa has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elservier. The institution of Dr. Cappa has received research support from Italian Minsitry of Health.
	No disclosure on file
	No disclosure on file
	No disclosure on file
Andrea Falini	No disclosure on file
Giancarlo Comi, MD (University Vita-Salute)	Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Aspen Healthcare. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Rewind.

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