Abstract Details

Title The burden of neurological disorders (1990-2013); preliminary findings of the Global Burden of Disease 2013 study

Topic Neuroepidemiology

Presentation(s) (-)

Poster/Presentation
Number 003

Objective

Background Burden of disease studies provide comparable information on the magnitude of mortality and morbidity for over 300 diseases and injuries by country to guide global, regional and national health policies

Design/Methods We classified neurological disorders into stroke, Alzheimer disease and other types of dementia (AD), Parkinson disease (PD), Epilepsy, Multiple sclerosis (MS), Migraine, Tension-type headache, Medication-overuse headache (MOH) and other disorders. We used epidemiological data from systematic review and different covariates in meta-regression models to estimate prevalence. Ensemble models were used to estimate disease-specific mortality rates. Estimated measures of deaths and prevalence were used to calculate DALYs.

Results In 2013, there were 6.4 (95%CI: 6.0-7.2) million deaths for stroke and 2.0 (95%CI: 1.9-2.1) million for the other neurological disorders, 85% of which were due to AD. The number of deaths from neurological disorders increased by 50% since 1990. Age-standardized death rates of stroke and epilepsy decreased by 22% and 23%, respectively, during 1990-2013 while the rates for AD (by 3%) and PD (by 28%) increased. Combining deaths (as premature years of life lost) and morbidity (as years lived with disability) in DALYs, neurological disorders represent 8.0% of global burden. Stroke is the largest contributor (4.6% of total DALYs), followed by migraine (1.18%), AD (0.91%) and epilepsy (0.55%).

Conclusions Neurological conditions are an important contributor to the global burden of disease. Aging of populations will lead to large increases in case numbers and deaths even if the rate of deaths due to the largest contributor, stroke, is declining.

Authors/Disclosures
Maziar Moradi-Lakeh	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Valery L. Feigin, MD, PhD, FAAN (AUT University)	Dr. Feigin has nothing to disclose.
	No disclosure on file

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