Of 25 patients, 22 (88%) had venoarterial-ECMO (9 cardiac arrest; 13 cardiogenic shock) and 3 (12%) had venovenous-ECMO cannulation. The median ECMO support time was 96 (IQR 26-181) hours. The most common ABI was hypoxic ischemic brain injury (44%), followed by intracranial hemorrhage (24%), and ischemic infarct (16%). Subarachnoid hemorrhage (20%) was the most common type of intracranial hemorrhage, followed by intracerebral hemorrhage (8%), and subdural hemorrhage (4%). The most common involved location for HIBI was cerebral cortices (82%) and cerebellum (55%). The pattern of ischemic infarct was territorial in cerebral cortices. Risk factors for ABI included hypertension history (11 vs. 1, p=0.01), pre-ECMO antiplatelet use (7 vs. 0, p=0.03), and a higher day 1 lactate level (10.0 vs. 5.1, p=0.02). Patients with HIBI more frequently had hypertension (8 vs. 4, p=0.047), higher day 1 lactate levels (12.6 vs. 5.8, p=0.02), and lower pH (7.09 vs. 7.24, p=0.027). ECMO duration, cannulation methods, hemoglobin level, coma, renal and hepatic impairment were not associated with ABI.