Abstract Details

Title Mapping the Imaging Correlates of Hand Motor Performance in Multiple Sclerosis: Focus on Structural and Functional Motor Networks

Topic Neuro-rehabilitation

Presentation(s) S42 - Neuro-rehabilitation (3:42 PM-3:54 PM)

Poster/Presentation
Number 002

Objective To assess the association between abnormalities in motor-related gray matter (GM) networks, white matter (WM) motor tracts and resting state (RS) functional connectivity (FC) of hand-motor networks with hand-motor performance, as well as with the global disability in multiple sclerosis (MS) patients.

Background Hand-motor impairment has a strong impact on daily-life activities in MS patients and MRI measures may contribute to better understand the substrates of these deficits.

Design/Methods 3D T1-weighted, diffusion tensor and RS functional MRI scans were acquired from 366 MS patients and 134 healthy controls (HC). Source-based morphometry, Diffusivity indexes analysis and seed-based analysis were performed on motor-relevant regions. Multivariate analyses identified the independent predictors of hand motor performance [9 Hole Peg Test (9HPT) and Finger Tapping (FT)], as well as the EDSS score.

Results

Compared with HC, MS patients showed significant atrophy in motor relevant GM networks, alteration of WM tracts integrity and abnormal RS FC (p<0.001). The multivariate analysis retained as best predictors of EDSS score (R²=0.40) age, lower normalized brain volume (NBV), cerebellar GM network atrophy and reduced right corticospinal tract fractional anisotropy (FA). Worse right-9HPT performance (R²=0.49) was predicted by progressive MS phenotype (PMS), reduced NBV, male-gender, reduced inferior and middle cerebellar peduncle FA and increased left inferior frontal gyrus RS FC. Best predictors of impaired left-9HPT (R²=0.49) were PMS, reduced left inferior cerebellar peduncle FA, higher T1 lesion volume, male-gender and age. Right-FT performance predictors (R²=0.40) were PMS, age, GM sensorimotor network atrophy, female-gender and reduced left postcentral gyrus RS FC. Finally, best predictors of left-FT performance (R²=0.41) were PMS, age, female-gender, reduced left paracentral lobule RS FC and GM cerebellar network atrophy.

Conclusions Patterns of GM atrophy in motor-related networks and microscopic abnormalities in motor-related WM tracts, combined with RS FC abnormalities of hand motor network contributed to explain hand-motor impairment in MS patients.

Authors/Disclosures
Claudio Cordani PRESENTER	Claudio Cordani has nothing to disclose.
Paola Valsasina	No disclosure on file
Alessandro Meani	No disclosure on file
Federica Esposito	Federica Esposito has received personal compensation in the range of $0-$499 for serving as a Consultant for Merck. Federica Esposito has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Federica Esposito has received personal compensation in the range of $0-$499 for serving as a Consultant for Novartis. Federica Esposito has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Federica Esposito has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. The institution of Federica Esposito has received research support from Italian MS Society. The institution of Federica Esposito has received research support from Italian Ministry of Health. The institution of Federica Esposito has received research support from ERA Net. The institution of Federica Esposito has received research support from European Commission. Federica Esposito has received intellectual property interests from a discovery or technology relating to health care.
Bruno Colombo	Bruno Colombo has nothing to disclose.
Elisabetta Pagani	Elisabetta Pagani has nothing to disclose.
Massimo Filippi, MD, FAAN (Ospedale San Raffaele, Neuroimaging Research Unit)	Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.
Maria A. Rocca (Neuroimaging Research Unit)	Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen, Bristol Myers Squibb, Eli Lilly, Janssen, Roche. Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AstraZaneca, Biogen, Bristol Myers Squibb, Bromatech, Celgene, Genzyme, Horizon Therapeutics Italy, Merck Serono SpA, Novartis, Roche, Sanofi and Teva. The institution of Maria Assunta Rocca has received research support from MS Society of Canada, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.

��ɫ��

��ɫ��