2015 Annual Meeting | The Dynamic Brain in Health and Disease: Plasticity and Reprogramming

Date Wednesday 04/22/15

Time 02:00 PM - 06:00 PM Add To Calendar

Session Format This program will be presented both in-person and online

On Demand This program is not expected to be available in the meeting's On Demand product.

Event Type Integrated Neuroscience

Director(s) Mark F. Mehler, MD, FAAN, Mark W. Albers, MD, PhD

Topic(s) Aging, Dementia, and Behavioral Neurology, Cerebrovascular Disease and Interventional Neurology, Child Neurology and Developmental Neurology, Neuro-rehabilitation, Movement Disorders, Neuro-oncology

Learning Objectives Participants will have an understanding of the physiologic and pathophysiologic diversity in the genome of single neurons within the human brain and an appreciation of the implications the impact of these mechanisms of diversity generation required to carry out the complex functions of the brain on the initiating and propagating mechanisms for neurologic disease. For instance, the role of mobile elements in the human genome to create genomics diversity within neurons during development and neuronal repair processes will be discussed as well as unregulated genomic perturbations via these mobile elements as an initiating or propagating mechanism for disease.

Participants will also have an appreciation of the generation of diversity on neural cell types through cellular reprogramming in the brain in vivo. Recent advances in our understanding to alter the identity of new cells born within the brain during development and in the adult brain, within “critical periods” of maximum plasticity that may be exploited for therapeutic purposes. In addition, participants will gain insights into neurologic disease pathogenesis and therapy that stem from iPS and direct cellular reprogramming from patients into neuronal subclasses that are relevant to the disease of interest (e.g. motor neurons from ALS; thalamocortical neurons in sleep disorders)

Participants will also gain an appreciation of the means that neurons respond to changes in network activity, including alterations of gene expression via directed movement of chromosomes within the nucleus, and via RNA biology. In addition, modulation of network learning that underlies motor recovery from acute injuries such as stroke and TBI, and the coupling local neural circuit activity related to social behavioral states with the rates of neurogenesis and integration of new neurons into the hippocampus will be discussed.

CME Available No CME available

Recommended Audience General Neurologist

Teaching Styles Didactic

Event Timeline
02:00 PM - 02:05 PM		Introduction
02:00 PM - 06:00 PM	Abstract	001 - The Longitudinal Relationship between Inflammatory Burden and Gait Speed is Influenced by White Matter Microstructural Characteristics: Secondary Analysis of the Health ABC Study.
02:00 PM - 06:00 PM	Abstract	002 - Cortical Reorganization and Magnetoencephalographic Correlates for Paretic Hand Recovery after Stroke Chih-Wei Tang, MD
02:00 PM - 06:00 PM	Abstract	003 - Brain structural abnormalities in patients with major depression with or without generalized anxiety disorder comorbidity Elisa Canu
02:00 PM - 06:00 PM	Abstract	004 - In Vitro and in Vivo Effects of Ionizing Radiation on Cell Cycle Progression and Self-Renewal of Subventricular Zone Neural Precursors
02:00 PM - 06:00 PM	Abstract	005 - Induction of Functional and Structural Plasticity by Intermittent Theta Burst Stimulation in Post-Stroke Aphasia Joseph C. Griffis
02:00 PM - 06:00 PM	Abstract	006 - Genetic Association Study of Cognitive Performance Jonathan E. Katz
02:00 PM - 06:00 PM	Abstract	007 - Tractography Activation Patterns in Dorsolateral Prefrontal Cortex suggest better clinical responses in Deep Brain Stimulation (DBS) of the Anterior Limb of the Internal Capsule and Nucleus Accumbens (ALIC-NA) for Obsessive-Compulsive Disorder (OCD)
02:00 PM - 06:00 PM	Abstract	008 - HDAC4 Shuttling Promotes Neuronal Remodeling After Stroke Amjad Shehadah, MD
02:00 PM - 06:00 PM	Abstract	009 - Personal Experience with Dance and Cortical Gray Matter Thickness in the Cognitively Normal and Mild Cognitive Impaired Elderly Shai Porat
02:00 PM - 06:00 PM	Abstract	010 - Network Control Theory as a Mediator of Transcranial Magnetic Stimulation Effects John D. Medaglia, PhD
02:00 PM - 06:00 PM	Abstract	011 - In vivo evidence for long-term potentiation in older adults.
02:00 PM - 06:00 PM	Abstract	012 - Deep repetitive transcranial magnetic stimulation and cycling improve lower limb function in chronic stroke: a randomized, placebo-controlled, crossover study Raffaella Chieffo, MD
02:00 PM - 06:00 PM	Abstract	013 - A Stimulating Idea: Treating Mixed ET/PD Tremor with Novel DBS Approach Ramsey A. Falconer, MD, FAAN
02:05 PM - 02:35 PM		New Treatments for Neurodevelopmental and Neurodegenerative Disorders Joseph Gleeson, MD
02:35 PM - 03:05 PM		Fate Plasticity in the Cerebral Cortex: Generating New Corticospinal Neurons Bradley Molyneaux, MD, PhD
03:05 PM - 03:35 PM		Novel Forms of Plasticity in the Adult Mammalian Brain Hongjun Song, PhD
03:35 PM - 04:05 PM		New Approaches to Promote Motor Recovery After Stroke John W. Krakauer, MD
04:05 PM - 04:10 PM		Genetic Association Study of Cognitive Performance Jonathan E. Katz
04:10 PM - 04:15 PM		Tractography Activation Patterns in Dorsolateral Prefrontal Cortex Suggest Better Clinical Responses in Deep Brain Stimulation (DBS) of the Anterior Limb of the Internal Capsule and Nucleus Accumbens (ALIC-NA) for Obsessive-Compulsive Disorder (OCD)
04:15 PM - 04:20 PM		HDAC4 Shuttling Promotes Neuronal Remodeling after Stroke Amjad Shehadah, MD
04:20 PM - 04:25 PM		Personal Experience with Dance and Cortical Gray Matter Thickness in the Cognitively Normal and Mild Cognitive Impaired Elderly Shai Porat
04:25 PM - 04:30 PM		Network Control Theory as a Mediator of Transcranial Magnetic Stimulation Effects John D. Medaglia, PhD
04:30 PM - 04:35 PM		In Vivo Evidence for Long-Term Potentiation in Older Adults
04:35 PM - 04:40 PM		Deep Repetitive Transcranial Magnetic Stimulation and Cycling Improve Lower Limb Function in Chronic Stroke: A Randomized, Placebo-Controlled, Crossover Study Raffaella Chieffo, MD
04:40 PM - 04:45 PM		A Stimulating Idea: Treating Mixed ET/PD Tremor with Novel DBS Approach Ramsey A. Falconer, MD, FAAN
04:45 PM - 05:15 PM		Guided Poster Rounds
05:15 PM - 06:00 PM		Roundtable Discussion

Faculty Disclosures
Mark F. Mehler, MD, FAAN	No disclosure on file
Mark W. Albers, MD, PhD	An immediate family member of Dr. Albers has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Aromha. Dr. Albers has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for Aromha. Dr. Albers has stock in Berkshire Hathaway. Dr. Albers has stock in Curis. The institution of Dr. Albers has received research support from NIH. Dr. Albers has received intellectual property interests from a discovery or technology relating to health care.
Bradley Molyneaux, MD, PhD	Dr. Molyneaux has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Molyneaux has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Billing, Cochran, Lyles, Mauro and Ramsey. The institution of Dr. Molyneaux has received research support from NIH. Dr. Molyneaux has received publishing royalties from a publication relating to health care.
	No disclosure on file
Raffaella Chieffo, MD	No disclosure on file
Ramsey A. Falconer, MD, FAAN	Dr. Falconer has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for Abbott. Dr. Falconer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Abbvie. Dr. Falconer has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for Amneal. Dr. Falconer has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for GE Health. Dr. Falconer has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Acorda. Dr. Falconer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Kyowa Kirin. Dr. Falconer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Neurocrine. Dr. Falconer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Supernus. Dr. Falconer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Sunovion. Dr. Falconer has received personal compensation in the range of $50,000-$99,999 for serving as an Expert Witness for Federal Trade Comission (FTC). Dr. Falconer has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Justice Department.
Amjad Shehadah, MD	Dr. Shehadah has nothing to disclose.
Jonathan E. Katz	No disclosure on file
John D. Medaglia, PhD	No disclosure on file
Shai Porat	No disclosure on file
Joseph Gleeson, MD	No disclosure on file
John W. Krakauer, MD	No disclosure on file
Hongjun Song, PhD	No disclosure on file
Yaakov Stern, PhD	Dr. Stern has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai. Dr. Stern has received intellectual property interests from a discovery or technology relating to health care. Dr. Stern has received publishing royalties from a publication relating to health care.
Howard Aizenstein, MD, PhD	No disclosure on file
Caterina Rosano, MD, MPH	No disclosure on file
I-Hui Lee, MD, PhD	Dr. Lee has nothing to disclose.
Clinton B. Wright, MD, FAAN	An immediate family member of Dr. Wright has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. An immediate family member of Dr. Wright has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for MARSHALL DENNEHY. The institution of an immediate family member of Dr. Wright has received research support from Oncospace. Dr. Wright has received publishing royalties from a publication relating to health care. An immediate family member of Dr. Wright has received personal compensation in the range of $500-$4,999 for serving as a surveyor with ASTRO.
Michael S. Okun, MD, FAAN	Dr. Okun has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for NIH. Dr. Okun has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Parkinson's Foundation. Dr. Okun has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JAMA Neurology. Dr. Okun has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for NEJM Journal Watch. The institution of Dr. Okun has received research support from NIH. The institution of Dr. Okun has received research support from Parkinson's Foundation. The institution of Dr. Okun has received research support from Tourette Association of America. The institution of Dr. Okun has received research support from Michael J Fox. Dr. Okun has received publishing royalties from a publication relating to health care.
Ihtsham Haq, MD, FAAN	The institution of Dr. Haq has received research support from NINDS. The institution of Dr. Haq has received research support from the Parkinson's Foundation.
Mauro Comola	No disclosure on file
Massimiliano Copetti	No disclosure on file
Federica Agosta	Federica Agosta has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philips. Federica Agosta has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier INC.
Roy H. Hamilton, MD, MS, FANA, FAAN	Dr. Hamilton has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Highland Instruments. Dr. Hamilton has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for McKnight Brain Research Foundation. Dr. Hamilton has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neurology (Journal). The institution of Dr. Hamilton has received research support from NIH. The institution of Dr. Hamilton has received research support from Department of Defense. The institution of Dr. Hamilton has received research support from Chan Zuckerberg Initiative.
Kirk R. Daffner, MD, FAAN	The institution of Dr. Daffner has received research support from Azheimer's Association.
Nizar Souayah, MD, FAAN	Dr. Souayah has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Takeda. Dr. Souayah has received publishing royalties from a publication relating to health care.
Kristine Yaffe, MD	Dr. Yaffe has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lilly. Dr. Yaffe has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Quintiles. Dr. Yaffe has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Alector. The institution of Dr. Yaffe has received research support from NIH. The institution of Dr. Yaffe has received research support from DOD. The institution of Dr. Yaffe has received research support from Veterans Affairs.
Oscar L. Lopez, MD, FAAN	Dr. Lopez has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Acumen.
Sean Rogers, MD, PhD	No disclosure on file
Giancarlo Comi, MD	Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Aspen Healthcare. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Rewind.
Elise Houdayer	No disclosure on file
Chih-Wei Tang, MD	No disclosure on file
Ralph L. Sacco, MD, MS, FAHA	Dr. Sacco has received personal compensation in the range of $100,000-$499,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Heart Association. The institution of Dr. Sacco has received research support from NIH, NINDS, NCATS, NIMHD. The institution of Dr. Sacco has received research support from FL Department of Health. Dr. Sacco has received research support from University of Washington, Seattle. Dr. Sacco has received publishing royalties from a publication relating to health care.
Liana Apostolova, MD, FAAN	Dr. Apostolova has received personal compensation in the range of $500-$4,999 for serving as a Consultant for NIH. Dr. Apostolova has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Apostolova has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Apostolova has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai. Dr. Apostolova has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech. Dr. Apostolova has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Apostolova has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech. Dr. Apostolova has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Alzheimer Association. An immediate family member of Dr. Apostolova has stock in Cassava Neurosciences. The institution of Dr. Apostolova has received research support from Roche Diagnostics. The institution of Dr. Apostolova has received research support from NIA. The institution of Dr. Apostolova has received research support from Alzheimer Association. The institution of Dr. Apostolova has received research support from AVID radiopharmaceuticals. The institution of Dr. Apostolova has received research support from Life Molecular Imaging.
Michael Chopp, PhD	No disclosure on file
Arturo Nuara	No disclosure on file
Kristy S. Hwang, MD	No disclosure on file
Massimo Filippi, MD, FAAN	Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.
Jane B. Allendorfer, PhD	The institution of Dr. Allendorfer has received research support from National Institutes of Health. The institution of Dr. Allendorfer has received research support from Evelyn F. McKnight Brain Institute. The institution of Dr. Allendorfer has received research support from LivaNova, Inc. Dr. Allendorfer has received personal compensation in the range of $500-$4,999 for serving as a Speaker with Cleveland Clinic. Dr. Allendorfer has received personal compensation in the range of $0-$499 for serving as a Examiner with University of Auckland. Dr. Allendorfer has received personal compensation in the range of $500-$4,999 for serving as a Speaker with International League Against Epilepsy. Dr. Allendorfer has received personal compensation in the range of $500-$4,999 for serving as a Grant Reviewer with Department of Defense. Dr. Allendorfer has a non-compensated relationship as a Scientific Program Committee Member with American Epilepsy Society that is relevant to AAN interests or activities. Dr. Allendorfer has a non-compensated relationship as a Editorial Board Member with Epilepsy and Behavior Reports that is relevant to AAN interests or activities.
Elisa Canu	The institution of Elisa Canu has received research support from Italian Ministry of Health .
Jerzy P. Szaflarski, MD, PhD, FAAN	Dr. Szaflarski has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UCB Pharma. Dr. Szaflarski has received personal compensation in the range of $500-$4,999 for serving as a Consultant for LivaNova Inc. Dr. Szaflarski has received personal compensation in the range of $500-$4,999 for serving as a Consultant for PureTech Health. Dr. Szaflarski has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Gidley, Sarli & Marusak, LLP. Dr. Szaflarski has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Szaflarski has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Law Firm. Dr. Szaflarski has stock in AdCel Biopharma, LLC. Dr. Szaflarski has stock in iFovea.
Letizia M. Leocani, MD	Dr. Leocani has received personal compensation in the range of $0-$499 for serving as a Consultant for Roche . Dr. Leocani has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Leocani has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Bristol Myers Squibb. Dr. Leocani has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Med-ex learning.
Naira Goukasian	No disclosure on file
Rodolphe Nenert	Rodolphe Nenert has nothing to disclose.
Farzaneh A. Sorond, MD, PhD	Dr. Sorond has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AbbVie. Dr. Sorond has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Stryker. The institution of Dr. Sorond has received research support from NIH.
Joseph C. Griffis	No disclosure on file
Roberto Santangelo	No disclosure on file

��ɫ��

��ɫ��