EMBARGOED FOR RELEASE UNTIL 4 PM ET, May 22, 2019
Bipolar Disorder May Be Linked to Parkinson鈥檚 Disease
MINNEAPOLIS -
People who have bipolar disorder may be more likely to later develop Parkinson鈥檚 disease than people who do not have bipolar disorder, according at a study published in the May 22, 2019, online issue of , the medical journal of the . 鈥淧revious studies have shown a relationship between depression and Parkinson鈥檚 disease, but few studies have looked at whether there is a relationship between bipolar disorder and Parkinson鈥檚,鈥 said study author Mu-Hong Chen, MD, PhD, of Taipei Veterans General Hospital in Taiwan. For the study, researchers examined a national Taiwanese health database for people were diagnosed with bipolar disorder between 2001 and 2009 and who had no history of Parkinson鈥檚 disease, for a total of 56,340 people. They were matched with 225,360 people of the same age, sex and other factors who had never been diagnosed with bipolar disorder or Parkinson鈥檚 disease as a control group. Then the two groups were followed until the end of 2011. During the study, 372 of the people with bipolar disorder developed Parkinson鈥檚 disease, or 0.7 percent, compared to 222 of those who did not have bipolar disorder, or 0.1 percent. After adjusting for other factors that could affect the risk of developing Parkinson鈥檚 disease, such as age, sex, use of antipsychotic medications, and medical issues such as traumatic brain injury and cerebrovascular diseases, people with bipolar disorder were nearly seven times as likely to develop Parkinson鈥檚 disease as people who did not have bipolar disorder. The people with bipolar disorder who developed Parkinson鈥檚 disease did so at a younger age than the control group members who developed the disease鈥64 years old at diagnosis compared to 73 years old. People who were hospitalized more often for bipolar disorder were more likely to develop Parkinson鈥檚 disease than those who were hospitalized less than once per year. A total of 94 percent of those with bipolar disorder were hospitalized less than once per year; 3 percent were hospitalized one to two times per year; and 3 percent were hospitalized more than two times per year. Those who were hospitalized more than two times per year were six times more likely to develop Parkinson鈥檚 disease than those who were hospitalized less than once per year. People who were hospitalized one to two times per year were four times more likely to develop Parkinson鈥檚 disease than those who were hospitalized less than once per year. 鈥淔urther studies are needed to investigate whether these diseases share underlying processes or changes in the brain,鈥 Chen said. 鈥淭hese could include genetic alterations, inflammatory processes or problems with the transmission of messages between brain cells. If we could identify the underlying cause of this relationship, that could potentially help us develop treatments that could benefit both conditions.鈥 A limitation of the study is it included only people who sought medical help for their bipolar disorder. Also, the database did not include information on family history of Parkinson鈥檚 disease or environmental factors that could increase people鈥檚 risk of developing the disease. The study was supported by Taipei Veterans General Hospital and the Taiwanese Ministry of Science and Technology. Learn more about the Parkinson's disease at , home of the 好色先生鈥檚 free patient and caregiver magazine focused on the intersection of neurologic disease and brain health. Follow Brain & Life庐 on , and .