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Abstract Details

Second Best: Non-Specific Speech Deficits in Logopenic Progressive Aphasia
Behavioral Neurology
S18 - (-)
001
Efforts to characterize lvPPA as distinct from other forms of PPA based on language-based clinical characteristics have met with difficulty. lvPPA patients exhibit speech production deficits in phonology, grammar, semantics, and discourse. However, the identification of a single feature that is diagnostic of lvPPA in connected speech has proved elusive.
We studied 43 patients with variants of PPA, including17 lvPPA; 9 semantic variant PPA (svPPA); 17 nonfluent/agrammatic PPA (naPPA); as well as 22 patients with Alzheimer's disease (AD); and 12 healthy seniors. A semi-structured speech sample was elicited by asking subjects to narrate a story from a children's wordless picture book. The speech samples were analyzed for features of fluency, phonology, grammar, semantics, and discourse. Voxel-based morphometry was used to relate gray matter atrophy to measures of performance.
lvPPA patients are second to naPPA in impairments of fluency as measured by such features as speech rate, speech errors, and false starts. They are also second to naPPA in grammatical measures such as proportion of sentences that are grammatical. They are second to svPPA patients in impairments of semantics such as open class word production, pronoun use, and absence of noun antecedents. They are second to AD in impairment on memory-based discourse measures such as global connectedness and maintenance of the theme of the story. Their speech production deficits are related to atrophy in left superior temporal cortex, angular gyrus, and insula.
lvPPA patients are difficult to distinguish from other PPA patients because their impairments cover a range of language production features and exhibit considerable variability.
Authors/Disclosures
Sharon Ash (University of Pennsylvania)
PRESENTER 		No disclosure on file
Danielle Weinberg No disclosure on file
No disclosure on file
Ashley Boller No disclosure on file
John Powers No disclosure on file
Corey McMillan, PhD (University of Pennsylvania) Dr. McMillan has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. The institution of Dr. McMillan has received research support from Biogen. The institution of Dr. McMillan has received research support from NIH.
Murray Grossman, MD, FAAN (University of Pennsylvania) Dr. Grossman has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neurology. The institution of Dr. Grossman has received research support from NIH.
Melissa Armstrong, MD, MSc, FAAN, FAAN (UF Department of Neurology) The institution of Dr. Armstrong has received research support from National Institute of Aging. The institution of Dr. Armstrong has received research support from Florida Department of Health. The institution of Dr. Armstrong has received research support from Lewy Body Dementia Association. Dr. Armstrong has received research support from Parkinson Foundation. Dr. Armstrong has received personal compensation in the range of $5,000-$9,999 for serving as a DSMB member with Alzheimer's Clinical Trials Consortium. Dr. Armstrong has received personal compensation in the range of $5,000-$9,999 for serving as a DSMB member with Alzheimer's Disease Cooperative Study. Dr. Armstrong has a non-compensated relationship as a Member, Scientific Advisory Council with Lewy Body Dementia Association that is relevant to AAN interests or activities.