Abstract Details

Title Preventing Loss of Independence through Exercise (PLIe): An Integrative Exercise Program for Individuals with Dementia

Topic Aging and Dementia

Presentation(s) S24 - (-)

Poster/Presentation
Number 007

Objective

Background Traditional exercise programs have been found to improve physical function in individuals with dementia, but less is known about the effects of exercises that integrate functional movements with mindful body awareness, which may also impact cognitive function.

Design/Methods The PLIe program incorporates elements of physical/occupational therapy, yoga, Tai Chi, Feldenkrais and Rosen Method and focuses on movements required to maintain function (e.g., standing from sitting) in a social group environment. An 18-week (45 minutes, 2-3 days/week) pilot-test was performed in 11 individuals (6 PLIe, 5 usual care, with group assignment based on sex and days of attendance) at a day care program in San Francisco, CA. Pre- and post-intervention data were collected by blinded assessors. Measures included the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog), 3-meter gait speed, and Caregiver Burden Inventory (CBI). Measures of effect size were calculated. Adverse events were monitored through biweekly caregiver check-ins.

Results PLIe and usual care groups were similar at baseline. ADAS-cog scores improved 4.6 points (27.0 to 22.4) with PLIe and worsened 2.4 points (23.7 to 26.1) with usual care (effect size, 0.76). Gait speed improved 0.3 seconds (5.7 to 5.4) with PLIe and worsened 0.8 seconds (5.4 to 6.2) with usual care (effect size, 0.53). CBI scores decreased 5.5 points (29.8 to 24.3) with PLIe and increased 1.8 points (32.5 to 34.3) with usual care (effect size, 0.51). There were no serious study-related adverse events.

Conclusions This pilot study provides preliminary evidence that the PLIe program may improve cognitive function, physical performance and caregiver burden when compared with usual care, with an effect size comparable to or exceeding currently available medications. A larger randomized, controlled trial is warranted.

Authors/Disclosures
Deborah E. Barnes, PhD, MPH PRESENTER	The institution of Dr. Barnes has received research support from the National Institutes of Health, Department of Veterans Affairs, Department of Defense, Alzheimer's Association, and the California Department of Public Health.
	No disclosure on file
Kristine Yaffe, MD	Dr. Yaffe has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lilly. Dr. Yaffe has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Quintiles. Dr. Yaffe has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Alector. The institution of Dr. Yaffe has received research support from NIH. The institution of Dr. Yaffe has received research support from DOD. The institution of Dr. Yaffe has received research support from Veterans Affairs.
	No disclosure on file
	No disclosure on file
Tanuja Chitnis, MD, FAAN (Brigham and Women's Hospital)	Dr. Chitnis has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novartis. Dr. Chitnis has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Roche-Genentech. Dr. Chitnis has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Siemens. Dr. Chitnis has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Octave Biosciences. Dr. Chitnis has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi. The institution of Dr. Chitnis has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Chitnis has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Academic CME. The institution of Dr. Chitnis has received research support from Novartis. The institution of Dr. Chitnis has received research support from Sanofi. The institution of Dr. Chitnis has received research support from Octave. The institution of Dr. Chitnis has received research support from Genentech-Roche. The institution of Dr. Chitnis has received research support from Tiziana Life Sciences. The institution of Dr. Chitnis has received research support from Bristol-Myers Squibb. The institution of Dr. Chitnis has received research support from Wesley Clover.
Emilio Portaccio	Emilio Portaccio has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Emilio Portaccio has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck Serono. Emilio Portaccio has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Emilio Portaccio has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Emilio Portaccio has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Emilio Portaccio has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Biogen. Emilio Portaccio has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck Serono. Emilio Portaccio has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Emilio Portaccio has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Emilio Portaccio has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Emilio Portaccio has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for BMS Cellgene.

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