Abstract Details

Title Pathways to Neurodegeneration: The Effects of HIV and Aging on Resting State fcMRI

Topic Infections/AIDS/Prion Disease

Presentation(s) S38 - (-)

Poster/Presentation
Number 001

Objective

Background HIV+ patients are now living longer as a consequence of highly active antiretroviral therapy (HAART). However, many HIV+ individuals continue to have cognitive impairment despite these medications. Older HIV+ patients may be at increased risk for developing neurodegenerative disorders.

Design/Methods This study used resting state functional connectivity magnetic resonance imaging (rs-fcMRI) to non-invasively investigate the neurobiology of five functionally defined brain networks in 52 HIV+ (44% on HAART) and 52 HIV- controls. Network composite scores were computed for five networks: default-mode network (DMN), control network (CON), salience network (SAL), dorsal attention network (DAN) and sensorimotor network (SMN). Independent changes in rs-fcMRI due to HIV and aging were assessed by ANCOVA.

Results A reduction in rs-fcMRI correlations was seen within the DMN (p=.003), CON (p=.006), and SAL (p=.03) networks while the DAN and SMN remained relatively spared. Compensatory increases in correlations were not seen within any networks. Neither markers of HIV (HIV viral load or CD4+ cell count) nor degree of cognitive impairment associated with HIV correlated with rs-fcMRI measures. Aging led to a decrease in correlations within the DMN (p=.03) and SAL (p=.006) networks for both HIV+ and HIV- subjects, however no interaction was present between HIV and aging.

Conclusions These results suggest that HIV and aging cause similar decreases in rs-fcMRI. HIV could serve as a model for accelerated neurodegeneration within brain network connections. Further longitudinal studies of older HIV+ patients are needed.

Authors/Disclosures
Jewell Thomas PRESENTER	No disclosure on file
Matthew Brier, MD, PhD (Washington University)	Dr. Brier has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Genentech. The institution of Dr. Brier has received research support from NIH.
	No disclosure on file
	No disclosure on file
Alastair Compston, PhD, FRCP	No disclosure on file
Beau M. Ances, MD, PhD, MS, FAAN (Washington University in Saint Louis)	Dr. Ances has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for NIH. Dr. Ances has received personal compensation in the range of $0-$499 for serving as an Expert Witness for Kinnard Lawyers.

��ɫ��

��ɫ��