Abstract Details

Title Lipid Differences in Two Hispanic Ischemic Stoke Populations

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) S52 - (-)

Poster/Presentation
Number 002

Objective

Background Significant differences in stroke mortality, risk factors and IC subtypes have been described between Hispanics and other subgroups. No study has systematically examined differences in lipid profiles across different Hispanic groups.

Design/Methods We analyzed IS Hispanic patients with complete baseline fasting lipid profile enrolled contemporaneously in the prospective registries of 2 tertiary care teaching hospitals in Mexico City and Miami. Demographic, risk factors, medications, TOAST subtype, and first fasting lipid profile were compared. Vascular risk factor definitions were standardized. Multiple lineal logistic regression analysis was performed to compare lipid fractions.

Results A total of 560 patients (324 from Mexico and 236 from Miami) were analyzed. Mexicans, were significantly younger (58.1 vs. 67.4 years), had a lower frequency of hypertension (53.4% vs. 79.7%), and lower body mass index (27 vs. 28.5). There was a trend towards greater prevalence of diabetes in Mexicans (31.5 vs. 24.6%, p=.07). Antilipidemics was more common in Miami Hispanics (18.6 vs. 9.4%). Mexicans had lower total cholesterol (TC) levels (169.9 ± 46.1 vs. 179.9 ± 48.8 mg/dl), low density lipoprotein (LDL) (92.3 ±37.1 vs. 108.2±40.8 mg/dl), non-high-density lipoprotein cholesterol (124.8±46.2 vs. 137.8±47.6 mg/dl) and lower lipid ratios (TC/HDL 4.2±1.6 vs. 4.6±1.8 and LDL/HDL 2.3±1.2 vs. 2.8±1.3). Mexicans had higher triglyceride levels (166.9±123.9 vs. 149.2±115.2 mg/dl). High-density lipoprotein (HDL) was similar. These differences remained significant after adjusting for age, sex, hypertension, diabetes, body mass index, smoking, stroke subtype and statin use.

Conclusions We found significant differences in lipid fractions, with lower LDL levels and higher TG levels in Mexicans. These findings highlight the heterogeneity of dyslipidemia among the Hispanic race-ethnic group. The underlying genetic and environmental contributions to these differences need to be further explored.

Authors/Disclosures
Antonio Arauz, MD, PhD (Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez) PRESENTER	Dr. Arauz has nothing to disclose.
Kailash P. Bhatia, MD, FAAN (UCL)	Dr. Bhatia has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ipsen. Dr. Bhatia has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for MDS . Dr. Bhatia has received publishing royalties from a publication relating to health care.
Jose G. Romano, MD, FAAN (University of Miami, Miller School of Medicine)	Dr. Romano has stock in Vycor Medical/NovaVision. The institution of Dr. Romano has received research support from NIH/NINDS. The institution of Dr. Romano has received research support from NIH/NHLBI.
	No disclosure on file
Tatjana Rundek, MD, PhD	The institution of Dr. Rundek has received research support from NIH.
Ty Shang, MD (UT Southwestern Medical Center)	No disclosure on file
	No disclosure on file
	No disclosure on file
Sebastian Koch, MD (University of Miami)	Dr. Koch has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Multiple Legal Matters. Dr. Koch has received stock or an ownership interest from Cerepeutics. Dr. Koch has received intellectual property interests from a discovery or technology relating to health care. Dr. Koch has received intellectual property interests from a discovery or technology relating to health care.
	No disclosure on file
Michael Katsnelson, MD	No disclosure on file
	No disclosure on file
Ralph L. Sacco, MD, MS, FAHA	Dr. Sacco has received personal compensation in the range of $100,000-$499,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Heart Association. The institution of Dr. Sacco has received research support from NIH, NINDS, NCATS, NIMHD. The institution of Dr. Sacco has received research support from FL Department of Health. Dr. Sacco has received research support from University of Washington, Seattle. Dr. Sacco has received publishing royalties from a publication relating to health care.

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