Abstract Details

Title T1-Rho and T2-Rho Relaxometry in Multiple Sclerosis

Topic MS and Related Diseases

Presentation(s) (-)

Poster/Presentation
Number 007

Objective

Background Quantitative MRI techniques can provide more specific measures of relevant pathologic processes in MS (such as demyelination, neurodegeneration, and iron deposition) than conventional MRI methods. Adiabatic T1-rho and T2-rho utilize rotating frame relaxations to provide enhanced sensitivity to molecular motion and generate novel MRI contrasts.

Design/Methods We investigated T1-rho and T2-rho relaxometry in four relapsing-remitting MS (RRMS) patients and four age- and gender-matched controls. The study was performed at a 4-T/90-cm Oxford magnet interfaced to a Varian INOVA console. The T1-rho and T2-rho measurements were obtained as in (Tuite et al 2012, Parkinsonism Rel Disord 18:623). R1-rho and R2-rho maps were generated in a single axial brain slice just above the lateral ventricles. Regions of interest including T2 lesions (T2L) and NAWM were identified from T2-weighted images from the MS subjects, and the corresponding regions were compared on the R1-rho and R2-rho maps from MS patients and controls.

Results T1-rho and T2-rho mapping showed systematic differences in MS brain tissue as compared to controls. In particular, T1-rho was significantly longer in MS patients as compared to controls, both in T2L and NAWM. T2-rho was also increased in T2L (to a lesser extent than T1-rho, however) but not in NAWM.

Conclusions T1-rho and T2-rho are novel MRI techniques that have been previously shown to reflect neuronal density and brain iron concentration, respectively. This pilot study shows that these techniques can detect tissue abnormalities in the MS brain, and should help improve our ability to detect and understand the focal and diffuse pathologic processes in MS.

Authors/Disclosures
Adam Carpenter, MD (Brain Sciences Center 11B) PRESENTER	An immediate family member of Dr. Carpenter has received personal compensation for serving as an employee of MarPam Pharma. The institution of Dr. Carpenter has received research support from Roche. The institution of Dr. Carpenter has received research support from Immune Tolerance Network. The institution of an immediate family member of Dr. Carpenter has received research support from NIH.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Mahlon R. DeLong, MD (Emory University SOM)	No disclosure on file

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