Abstract Details

Title Regional Hippocampal Involvement Differs across Multiple Sclerosis Clinical Phenotypes: A Radial Mapping MR-Based Study

Topic MS and Related Diseases

Presentation(s) (-)

Poster/Presentation
Number 004

Objective

Background Emerging data support the notion of a hippocampal demyelination and neurodegeneration early and throughout the course of MS.

Design/Methods Brain dual-echo and 3D T1-weighted scans were acquired from 115 MS patients (28 relapsing remitting [RR], 34 secondary progressive [SP], 27 primary progressive [PP], 26 benign [B] MS) and 28 healthy controls (HC). Hippocampal segmentation was performed manually according to standardized procedures, and global volumes derived. From contours, radial atrophy distribution was assessed using three-dimensional parametric surface mesh models.

Results Right and left hippocampal volumes differed significantly between groups (p<0.001 and p=0.001 respectively). Significant differences were found, for the right and left hippocampus respectively, in: RRMS vs. HC (p=0.002, p=0.01) and SPMS vs. PPMS (p=0.031, n.s.). When compared to HC, RRMS patients showed significant radial atrophy (p<0.001) involving the CA1 subfield and the subiculum of the left posterior hippocampus, and the right hippocampal head. Compared to HC, PPMS patients had a significant volume loss affecting lateral CA1, bilaterally, and right tail subicular region, with mild involvement of the right hippocampal head. Compared to RRMS and PPMS, SPMS patients showed atrophy of the left hippocampal head. Compared to RRMS, BMS patients had focal atrophy of the left hippocampal body. Significant correlations (r ranging from -0.2 to -0.5; p<0.001) were found between T2 and T1 lesion load and atrophy of subiculum and CA1 of posterior hippocampus and CA1 subregion of hippocampal head, bilaterally.

Conclusions Regional hippocampal atrophy differs among the major MS phenotypes, possibly reflecting differential susceptibility to inflammatory insults and neurodegenerative processes of the hippocampal subfields.

Authors/Disclosures
Giulia Longoni, MD (The Hospital for Sick Children) PRESENTER	Dr. Longoni has nothing to disclose.
Wolfgang Heide, MD, FEAN (AKH Celle)	No disclosure on file
Maria A. Rocca (Neuroimaging Research Unit)	Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen, Bristol Myers Squibb, Eli Lilly, Janssen, Roche. Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AstraZaneca, Biogen, Bristol Myers Squibb, Bromatech, Celgene, Genzyme, Horizon Therapeutics Italy, Merck Serono SpA, Novartis, Roche, Sanofi and Teva. The institution of Maria Assunta Rocca has received research support from MS Society of Canada, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.
Elisabetta Pagani	Elisabetta Pagani has nothing to disclose.
Vittorio Martinelli (S. Raffaele Hospital)	Dr. Martinelli has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis, Biogen, Sanofi Genzyme, TEVA and Merck. Dr. Martinelli has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck .
	No disclosure on file
Andrea Falini	No disclosure on file
Giancarlo Comi, MD (University Vita-Salute)	Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Aspen Healthcare. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Rewind.
Massimo Filippi, MD, FAAN (Ospedale San Raffaele, Neuroimaging Research Unit)	Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.

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