Abstract Details

Title Seeking the Extreme Delta Brush: Review of EEG Data from Two Cases of NMDA Receptor-AB Encephalitis

Topic Clinical Neurophysiology

Presentation(s) IN9 - (-)

Poster/Presentation
Number 008

Objective

Background NMDARe is an uncommon entity that presents with a constellation of symptoms including psychiatric changes, memory difficulties, seizures, alteration of consciousness, autonomic instability, and movement disorders. EEG is useful for the detection and treatment of status epilepticus, but has thus far had limited utility in diagnosis. The most commonly reported EEG finding is diffuse delta slowing. Schmitt and colleagues (2012) recently described the unique finding of the extreme delta brush in 7 of 23 patients with NMDARe who underwent continous EEG monitoring. This finding has thus far not been validated by other reports.

Design/Methods This is a retrospective review of all cases of NMDARe that were diagnosed at the University of Rochester Medical Center in the past five years. Two cases were identified. All collected EEG data from these cases were reviewed for evidence of the extreme delta brush.

Results Of the two cases reviewed, one had an EEG which demonstrated the extreme delta brush pattern. The other case demonstrated non-specific diffuse slowing.

Conclusions This case of NMDARe with the extreme delta brush pattern constitutes 12.5% (1 of 8) of the total reported cases with this finding and supports the validity of the EEG finding. It is important to acknowledge this EEG pattern because recognizing it may assist in the diagnosis of a treatable disease with a somewhat protean presentation.

Authors/Disclosures
Adam P. Juersivich, MD PRESENTER	No disclosure on file
Supurna Ghosh, PhD (Revalesio)	Dr. Ghosh has received personal compensation for serving as an employee of Revalesio Corporation.

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