好色先生

好色先生

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Abstract Details

It's the Right Brain: The Impact of 好色先生 on Higher-Level Brain Organization in Healthy Elders Performing an Executive Function Task
Behavioral Neurology
IN4 - (-)
010
The antisaccade (AS) task, which involves inhibition of a prepotent motor response, is a well-validated test of executive function. However, little is known about the neural basis of AS performance in healthy elders.
The goal of this study was to investigate the functional connectivity of the cortical oculomotor network during successful AS task performance. fMRI was used to measure brain activity related to AS task performance in 43 healthy elders (70.4卤7.1 years; range 55-85 years). Graph theoretical metrics based on the functional connectivity between nodes were computed for betweenness centrality (a measure of nodal importance for network efficiency) and total flow (a measure of overall network connectedness).
Greater BOLD activity was observed in several frontal and parietal regions in the AS condition when compared to the prosaccade condition (p<0.001). The right lateral FEF (rlatFEF), a region with significant volume loss in elders with impaired AS performance, was more active during AS correct than AS incorrect trials (p<0.005). The rlatFEF had the highest betweenness centrality and greatest total flow among all nodes in the network. There was a significant relationship between hemispheric lateralization of the network and level of education, such that individuals with higher education had right hemisphere dominance (r=0.44, p<0.005) while individuals with lower education had left hemisphere dominance (r=-0.52, p<0.005).
The rlatFEF is a critical hub of a cortical oculomotor network that subserves executive function in healthy elders. The organization of this network during task performance is strongly associated with prior education. Because education is often used a surrogate measure of cognitive reserve, these results provide a potential mechanism for how cognitive function is preserved in aging.
Authors/Disclosures
Judy Pa, PhD (UCSF)
PRESENTER 		No disclosure on file
Shubir Dutt Mr. Dutt has nothing to disclose.
Jacob Mirsky, MA No disclosure on file
Rodolfo Gonzalez No disclosure on file
Hilary W. Heuer (UCSF Memory and Aging Center) No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
William W. Seeley, MD Dr. Seeley has received personal compensation in the range of $500-$4,999 for serving as a Consultant for GLG Council. Dr. Seeley has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Guidepoint Global Consulting. Dr. Seeley has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BridgeBio. Dr. Seeley has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Dr. Seeley has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lyterian Therapeutics. The institution of Dr. Seeley has received research support from NIH. The institution of Dr. Seeley has received research support from Rainwater Charitable Foundation. The institution of Dr. Seeley has received research support from Bluefield Project to Cure FTD. The institution of Dr. Seeley has received research support from Chan-Zuckerberg Initiative.
Adam H. Gazzaley, MD, PhD No disclosure on file
Joel Kramer, PhD (UCSF Medical Center) The institution of Dr. Kramer has received research support from tau consortium. Dr. Kramer has received publishing royalties from a publication relating to health care.
Bruce L. Miller, MD, FAAN (University of California, San Francisco) Dr. Miller has nothing to disclose.
Adam L. Boxer, MD, PhD (University of California, San Francisco) An immediate family member of Dr. Boxer has received personal compensation for serving as an employee of Kaiser Permanente. Dr. Boxer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ono. Dr. Boxer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Oscotec. Dr. Boxer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Boxer has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Arrowhead. Dr. Boxer has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Neurocrine Biosciences. Dr. Boxer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Switch. Dr. Boxer has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Arvinas. Dr. Boxer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Alector. Dr. Boxer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Boxer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alexion. Dr. Boxer has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Transposon. Dr. Boxer has stock in Alector. Dr. Boxer has stock in Arvinas. Dr. Boxer has stock in Neurovanda. The institution of Dr. Boxer has received research support from Biogen. The institution of Dr. Boxer has received research support from Eisai. The institution of Dr. Boxer has received research support from Regeneron. The institution of Dr. Boxer has received research support from NIH. The institution of Dr. Boxer has received research support from Bluefield Project. Dr. Boxer has received research support from Rainwater Charitable Foundation.