Abstract Details

Title Lower CSF Hypocretin-1 Levels Correlate with Insomnia in HIV-Seropositive Women

Topic Infections/AIDS/Prion Disease

Presentation(s) IN8 - (-)

Poster/Presentation
Number 005

Objective

Background Insomnia is frequent in HIV-seropositive persons and women and dysfunction in the hypocretin/orexin (hcrt/ox) system of hypothalamic peptide has been related to narcolepsy and insomnia. Hypothalamic dysfunction was has also been shown to be associated with mood disorders in drug abusing HIV-seropositive patients.

Design/Methods In a retrospective study of 28 HIV-seropositive, 29 HIV-seronegative, and 5 CSF controls women we used the ATHENA scale to stratify participants by the presence of insomnia. There were no differences in age, BMI, and BDI observed between HIV-seropositive or negative groups. All participants were negative for toxicology. CSF hcrt/ox levels were determined using the fluorescent immunoassay kit, (Phoenix Pharmaceuticals) with an intra- and inter-assay validity of 10% and 15% respectively. The association between CSF hcrt/ox and insomnia was tested using parametric and non parametric statistics, as appropriate. Statistical significance was determined at p<.05.

Results There was no association between insomnia and HIV serostatus. Among HIV-seropositive women, presence of insomnia was associated with an increased CD4 cell count,. There was no association between presence of insomnia and other measures (CPE, cART, use of protease inhibitors, and depressive symptoms). CSF hcrt/ox levels were higher in HIV-seropositive women when compared with the 5 CSF controls. HIV-seropositive women CSF hcrt/ox levels correlated with age, HCV, and CPE; being higher among those older and with HCV, and higher CPE levels. When controlling for the influence of age, HCV, and CPE, presence of insomnia was associated with lower CSF hcrt/ox levels among HIV-seropositive women.

Conclusions Our study demonstrated that lower CSF hcrt/ox levels were associated with insomnia among HIV-seropositive women. These findings sustain prior evidence of hypothalamic dysfunction among HIV-seropositive persons. Further studies should be performed to support these results.

Authors/Disclosures
Rafael J. Lopez-Baquero, MD (RLB Neurology) PRESENTER	Dr. Lopez-Baquero has nothing to disclose.
	No disclosure on file
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Valerie E. Wojna, MD, FAAN (Nuerology Division, UPR MSC SoM)	Dr. Wojna has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Puerto Rico Health Sciences Journal, University of Puerto Rico Medical Sciences Campus. The institution of Dr. Wojna has received research support from NIH.

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