Abstract Details

Title BMI and Diabetes Do Not Influence Post-stroke Fatigue

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) S43 - Stroke Recovery and Outcomes (5:06 PM-5:18 PM)

Poster/Presentation
Number 009

Objective To determine how body-mass index (BMI) and diabetes independently influence post-stroke fatigue (PSF).

Background PSF is a common, important but poorly understood cause of long-term morbidity in cerebrovascular disease. The obesity paradox notes that while obesity is a major risk factor for stroke, being overweight or obese is associated with lower mortality and better stroke outcomes. This is in contrast with diabetes, which increases both stroke mortality and adversely affects post stroke outcomes. How diabetes and obesity mediate PSF specifically as an outcome is unclear.

Design/Methods An observational, cross-sectional, 2-site, prospective study at SUNY Downstate Health Sciences University and Kings County Hospital Center enrolled 98 patients age >18 diagnosed with ischemic stroke within the past 3 years without pre-existing physical or mental conditions. PSF was evaluated, using the validated, quantitative Fatigue Assessment Scale (FAS), along with history, examinations, and diagnostic testing. Box and whisker plots were used for BMI (normal/overweight/obese) vs. total FAS, Spearman correlation coefficient was calculated for raw BMI vs. FAS, and Fisher exact test for BMI, diabetes, and fatigue (FAS: no fatigue ≤21, fatigue 22-50).

Results Of 98 patients with a history of ischemic stroke, 26% were of normal BMI (<25 kg/m²), 32% were overweight, and 43% were obese. 40 patients had PSF, of which 9 were overweight, 18 were obese, and 25 had diabetes. In a scatter plot, there was no association between BMI and FAS score (r= +0.06, p= 0.557). The generalized Fisher exact test was used to assess association of dichotomized FAS with diabetes & categorized BMI (normal, overweight, obese) and no association was found.

Conclusions While obesity and diabetes are risk factors for stroke, we could not confirm that higher BMI leads to less PSF as the obesity paradox predicts. We could not detect an increased risk of PSF in the presence of diabetes.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
Nadege Gilles (SUNY Downstate Medical Center)	Ms. Gilles has nothing to disclose.
	No disclosure on file
Susan W. Law, DO (NYC HEALTH AND HOSPITAL / KINGS COUNTY)	Dr. Law has nothing to disclose.
	No disclosure on file
Steven Levine, MD, FAHA (SUNY Downstate Medical Center)	Dr. Levine has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for MEDLINK. Dr. Levine has received personal compensation in the range of $50,000-$99,999 for serving as an Expert Witness for Law Firms. The institution of Dr. Levine has received research support from NIH.

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