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Abstract Details

Mortality and Functional Outcomes After Minimally Invasive Endoscopic Intracerebral Haemorrhage Evacuation
Cerebrovascular Disease and Interventional Neurology
S9 - Cerebrovascular Disease: Intracerebral Hemorrhage (3:42 PM-3:54 PM)
002

We aim to describe our positive findings in the first cohort of patients to undergo a novel neuroendoscopic technique for intracerebral haemorrhage evacuation developed at our centre called Stereotactic Intra-Cerebral Haemorrhage Underwater Blood Aspiration (SCUBA).

Spontaneous intracerebral haemorrhage (ICH) is associated with high rates of mortality. Numerous prognostic scoring systems exist however the original ICH Score remains most widely used. Phase 3 of the anticipated MISTIE trial demonstrated no overall benefit to stereotactic catheter drainage. In subgroup analysis, favourable outcomes were noted in 57% of patients reaching the surgical goal of ≤15mL end-of-treatment volume. SCUBA has previously been reported to achieve high hematoma evacuation efficacy. We hypothesize that patients undergoing SCUBA will have lower 30-day mortality than predicted by the ICH Score.

100 consecutive supratentorial non-traumatic spontaneous ICH underwent SCUBA at a dedicated ICH centre between December 2015 – October 2018. Patient eligibility included: age ≥18, premorbid mRS ≤3, NIHSS ≥6 and hematoma volume ≥15mL. Patients were studied prospectively with 30-day mortality and 180-day disability as primary outcomes. Observed 30-day mortality was compared with the expected mortality given the patients’ calculated pre-operative ICH Score.

The median age was 60 (IQR 53-73), GCS 10 (7-13), and NIHSS 17 (13-22). 63 patients had deep haemorrhage and 43 had intraventricular haemorrhage. Median pre-operative and post-operative volume was 40.9mL (27.8-64.3) and 1.2mL (0.2-64), respectively. Whilst the expected 30-day mortality was 34.7%, the observed mortality was 9%. At 180-day follow-up, a good outcome to moderate disability, defined as mRS of 0-3, was observed in 46% of patients.
Patients undergoing SCUBA have a 25.7% risk reduction in mortality than predicted by the ICH score. Favourable functional outcome was achievable in almost half the patients. These findings support the need for a randomized control trial to further explore the safety and efficacy of this promising technique.
Authors/Disclosures
Miryam Alkayyali, MD (Icahn School of Medicine at Mount Sinai)
PRESENTER
Dr. Alkayyali has nothing to disclose.
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
Christopher P. Kellner, MD (Mount Sinai Health System) Dr. Kellner has stock in METIS Innovative. Dr. Kellner has stock in Precision Recovery. Dr. Kellner has stock in Synchron. Dr. Kellner has stock in Fluid BioMed. Dr. Kellner has stock in Proprio. Dr. Kellner has stock in Von Vascular. Dr. Kellner has stock in E8. Dr. Kellner has stock in Borvo. Dr. Kellner has stock in Phantom Neuro. Dr. Kellner has stock in Radical. Dr. Kellner has stock in Reach Neuro. Dr. Kellner has stock in Aurenar. The institution of Dr. Kellner has received research support from Integra. The institution of Dr. Kellner has received research support from Penumbra. The institution of Dr. Kellner has received research support from Viz.AI. The institution of Dr. Kellner has received research support from ICE Neurosystems. The institution of Dr. Kellner has received research support from Irras. The institution of Dr. Kellner has received research support from Microtransponder. The institution of Dr. Kellner has received research support from Medtronic. The institution of Dr. Kellner has received research support from Longeviti. The institution of Dr. Kellner has received research support from Endostream. The institution of Dr. Kellner has received research support from CVAID.
John Liang, MD (Mount Sinai Health System) Dr. Liang has nothing to disclose.