Abstract Details

Title The Effects of Paternal Seizure Disorders and Antiseizure Medication Use on Offspring Neurodevelopmental Outcomes, Psychiatric Comorbidities, and Sexual Health.

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) S25 - Epilepsy/Clinical Neurophysiology (EEG) 2 (1:48 PM-2:00 PM)

Poster/Presentation
Number 005

Objective To determine if men with epilepsy on antiseizure medications at the time of conception have difficulty conceiving children, both due to biological and psychological impediments. Additionally, the neurodevelopmental outcomes of their offspring are analyzed, as are the incidences of psychiatric comorbidities and altered sexual performance.

Background

There are few studies that evaluate the effects of antiseizure medications on men and their offspring.

Design/Methods A total of 450 male patients with and without epilepsy at one hospital were provided questionnaires to determine demographic characteristics, epilepsy history, type of antiseizure medication at the time of conception, subsequent childhood birth and developmental history, and sexual health. Survey data was evaluated using descriptive statistical analysis: Student’s t-test for continuous variables and Fischer’s exact test for categorical variables. Prevalence odds ratio (pOR) were calculated to determine associations between the measured data.

Results After matching by age, we analyzed a total of 110 males with epilepsy and 110 without epilepsy. Keppra and lacosamide were the most common antiseizure medications used in the epilepsy group. A higher rate of autism spectrum disorder and developmental delays were seen in offspring conceived by men on antiseizure medication when compared to control groups (N=17, pOR 8.44; 95% IC: 0.99-72.03, p=0.03). There was a higher rate of psychiatric comorbidities such as major depressive disorder, general anxiety disorder, bipolar disorder, and suicidal ideation in participants with epilepsy when compared to the control group (N=110; pOR 3.39; 95% IC: 1.87-6.13, p<0.001). Males with epilepsy had a higher frequency of low erection scores when compared to males without epilepsy (N=110; pOR 3.67; 95% IC: 1.44-9.39, p=0.005).

Conclusions

The present study suggests men with epilepsy on antiseizure medications have higher rates of developmental disorders in their offspring, an increased incidence of psychiatric comorbidities, and changes in sexual performance, specifically erectile dysfunction, when compared with men without epilepsy.

Authors/Disclosures
Hernan Nicolas Lemus Esquivel, MD (The University of Alabama at Birmingham) PRESENTER	Dr. Lemus Esquivel has nothing to disclose.
Marc J. Casale (Icahn School of Medicine At Mount Sinai)	No disclosure on file
James Young, MD (Icahn School of Medicine At Mount Sinai)	No disclosure on file
Lara V. Marcuse, Sr., MD (Mount Sinai)	Dr. Marcuse has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Neuropace.
Ji-Yeoun Yoo, MD	Dr. Yoo has received publishing royalties from a publication relating to health care.
Bridget R. Mueller, MD, PhD (Icahn School of Medicine At Mount Sinai)	Dr. Mueller has nothing to disclose.
Madeline C. Fields, MD (The Mount Sinai Hospital)	Dr. Fields has nothing to disclose.

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