Abstract Details

Title Differences in Subthalamic Oscillatory Neurons Associated with Severity in Parkinson’s Disease

Topic Movement Disorders

Presentation(s) S55 - Movement Disorders: Neuromodulation, Circuits, and Management (3:42 PM-3:54 PM)

Poster/Presentation
Number 002

Objective

To investigate whether altered neuronal activity in the subthalamic nucleus (STN) is associated with severity in patients with Parkinson’s disease (PD).

Background PD is a progressive degenerative disorder. Abnormal activity in the basal ganglia is thought to underlie the mechanism of PD.

Design/Methods Thirty patients who received bilateral STN DBS treatment were studied. Microelectrode recording in STN was performed. Single unit analysis including interspike interval (ISI) and coefficient of variation of ISI (CV) were analyzed. Power spectral analysis was done. UPDRS III was obtained. The early stage (moderate symptoms) and the advanced stage (severe symptoms) were defined based on lateralized UPDRS III scores during “off” medication, disease duration, and the side of initial symptoms. For the advanced stage group, the UPDRS III scores were ≥20, the side of initial symptoms disease duration at > 8 year. The neuronal activity between two groups was compared.

Results 271 neurons with mean firing rate (MFR) 41.2 ± 1.2 Hz identified from advanced stage group and 241 neurons with MFR 34.8± 1.2 Hz identified from early stage group (p<0.001). Power spectral analysis showed 34.9% (84/241) ß oscillatory neurons in the early stage group and 51.3% (139/271) ß oscillatory neurons in the advanced stage group (P<0.01). In contrast, there were 34.9% (84/241) tremor frequency oscillatory neurons in the early stage group and 21.4% (58/271) tremor frequency oscillatory neurons in the advanced group (P<0.05). Further comparisons show that there were significant differences of MFR and CV between neurons (n=221) of the early and advanced stage groups (MFR: 34.8± 9.4 Hz vs 41.5±11.0 Hz P<0.01; CV: 1.07±0.02 vs.1.02 ±0.02, P<0.02).

Conclusions

The results suggest that subthalamic neuronal firing rate and proportion of ß oscillatory neurons increase with PD progression. This result is compatible with the rate theory of PD and could be due to loss of dopaminergic input to the striatum.

Authors/Disclosures
Ping Zhuang, PhD PRESENTER	Dr. Zhuang has nothing to disclose.
Mark Hallett, MD, FAAN (National Institutes of Health)	Dr. Hallett has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Hallett has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Neurocrine. Dr. Hallett has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Brainsway. Dr. Hallett has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for VoxNeuro. Dr. Hallett has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for QuantalX. Dr. Hallett has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Hallett has received intellectual property interests from a discovery or technology relating to health care. Dr. Hallett has received publishing royalties from a publication relating to health care. Dr. Hallett has received publishing royalties from a publication relating to health care. Dr. Hallett has received publishing royalties from a publication relating to health care. Dr. Hallett has received publishing royalties from a publication relating to health care. Dr. Hallett has received personal compensation in the range of $500-$4,999 for serving as a Speaker with International Parkinson and Movement Disorder Society. Dr. Hallett has a non-compensated relationship as a Past-President with Functional Neurological Disorder Society that is relevant to AAN interests or activities.
	No disclosure on file
	No disclosure on file
	No disclosure on file
Yongjie Li (Massachusetts General Hospital)	No disclosure on file

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