Abstract Details

Title Optic Nerve Head Volume is Significantly Decreased in Pediatric MS and Not Pediatric MOG-related Disorders.

Topic Multiple Sclerosis

Presentation(s) S24 - Pregnancy, Pediatric MS, and Early MS (3:42 PM-3:54 PM)

Poster/Presentation
Number 002

Objective

To compare optic nerve head (ONH) characteristics of youth with MS and myelin oligodendrocyte glycoprotein (MOG)-associated disorders with a healthy control (HC) population.

Background

Youth with MS and MOG-associated disorders exhibit changes in Retinal Nerve Fiber Layer (RNFL) and Ganglion Cell Inner Plexiform Layer (GCIPL) thickness, but knowledge about abnormalities in ONH morphology in these groups is lacking.

Design/Methods

Standardized OCT data (Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA)) were collected on HC (n=27(16F), median age 15y (IQR1.3)), youth with MS (n=17(11F), 16.9y (1.5), disease duration 2.6y (2.8)), and youth with MOG-related disorders (n=13(11F), 11.5y (4.2), 1.7y(1.3)). ONH parameters (total ONH volume (TV), Bruch’s membrane opening (BMO) region volume (BMO-Vol), and BMO minimal rim width (BMO-MRW)) were computed by triangulated 3D surface reconstruction. Mean peripapillary RNFL and macular GCIPL were derived from manufacturer’s fully-automated segmentation software, and results manually reviewed where necessary. Multivariable mixed effects models were used to model the five ONH parameters between groups, accounting for age at OCT, eye-specific number of optic neuritis episodes, and a subject-specific random intercept. Results were Bonferroni adjusted for multiple comparisons (p = 0.01).

Results

MS participants showed lower ONH TV (-.24 mm³,SE.073,p=.002), BMO-Vol (-.22 mm3,SE.083, p=.012), and BMO-MRW (-.42 d_MRW,SE.014,p=.004) compared to HC. ONH parameters were not different in MOG patients versus HC. Neither RNFL nor GCIPL were significantly different between HC and MS. GCIPL was lower in MOG than HC (-7.9 μm,SE3.05,p=.012).

Conclusions

Our analysis showed ONH volume loss in pediatric MS despite no significant differences in RNFL or GCIPL in comparison to HC. These differences, except for a lower GCIPL, were not present in MOG versus HC. ONH analysis may therefore be superior to RNFL or GCIPL in detecting anterior visual pathway injury in MS early in the disease course. Larger studies are needed to confirm these findings.

Authors/Disclosures
Giulia Longoni, MD (The Hospital for Sick Children) PRESENTER	Dr. Longoni has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Alexander U. Brandt, MD (Charite - Universitatsmedizin Berlin)	No disclosure on file
E. Ann Yeh, MD, MA, FRCPC (Hosptial for Sick Children)	Dr. Yeh has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Yeh has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for PRIME. Dr. Yeh has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Yeh has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. The institution of Dr. Yeh has received research support from Biogen. The institution of Dr. Yeh has received research support from Stem Cell Network. The institution of Dr. Yeh has received research support from CIHR. The institution of Dr. Yeh has received research support from Ontario Institute for Regenerative Medicine. The institution of Dr. Yeh has received research support from National MS Society. The institution of Dr. Yeh has received research support from NIH. The institution of Dr. Yeh has received research support from SickKids Foundation. The institution of Dr. Yeh has received research support from CMSC. The institution of Dr. Yeh has received research support from MSSC.

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