Abstract Details

Title Prevalence of Medical Comorbidities Following Concussion – Experience at Two Academic Institutions over 19 years

Topic Neuro Trauma, Critical Care, and Sports Neurology

Presentation(s) S30 - Sports Neurology and Neuro Trauma (3:30 PM-3:42 PM)

Poster/Presentation
Number 001

Objective The purpose of this study is to assess the prevalence of selected medical and psychiatric comorbidities following concussive mild Traumatic Brain Injury (TBI).

Background Concussion is a major public health problem due to its prevalence in elderly, contact, and collision sports. A growing body of evidence suggests that TBI patients are at elevated risk for long-term chronic health conditions. Most of the prior studies evaluated the epidemiology of comorbidities focusing on moderate and severe TBI, and they were not clear whether the comorbidities had pre- or post-dated the injury.

Design/Methods Institutional databases at two academic institutions were surveyed to identify patients admitted with a concussion between 2000-2019. Concussion and comorbidities, including hypertension, diabetes, hyperlipidemia, obesity, anxiety, depression, and sleep disorder, were defined as ICD-10 diagnosis codes. Concussion patients with preexisting comorbidities were excluded, and those without a known history of comorbidities before concussion were identified and followed up over time.

Results A total of 2368 concussion patients (mean age=54±18 years, 64% female) were identified, of which 59% were less than 60-year-old. Anxiety was the most common comorbidity to occur (21.6%) post-concussion followed by sleep disorders (18%), obesity (17.8%), depression (17.6%), hypertension (14%), hyperlipidemia (11.5%) and diabetes (5.8%). Post-concussion, females were more prone to have obesity, hypertension, anxiety compared to males (p<0.05). Patients above the age of 60 were more likely to have obesity, hyperlipidemia, and diabetes compared to less than 60 cohort (P <0.05). However, sleep, and anxiety disorders were more likely to occur in 40-60-year-old cohort compared to less than 40-year-old (p<0.05).

Conclusions Post-concussion, patients are at potential risk of multi-system comorbidities during their long-term course of recovery. Future prospective studies are warranted to learn more about the timing of onset of medical comorbidities and determine their impact on long-term outcomes post-TBI.

Authors/Disclosures
PRESENTER	No disclosure on file
Ali Al Jarrah	No disclosure on file
Ayaz M. Khawaja, MD	Dr. Khawaja has nothing to disclose.
	No disclosure on file
Saef Izzy, MD, FAAN (Brigham and Women'S Hospital, Harvard Medical School)	The institution of Dr. Izzy has received research support from NINDS. The institution of Dr. Izzy has received research support from The Gillian Reny Stepping Strong Center for Trauma Innovation. Dr. Izzy has received publishing royalties from a publication relating to health care.

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