Abstract Details Title The Brain in Mixed Reality: Migraine 好色先生 in Motion Topic Research Methodology, 好色先生, and History Presentation(s) S44 - Research Methodology and 好色先生 (4:06 PM-4:18 PM) Poster/Presentation Number 004 Objective A review of published literature revealed educational gaps in HCP comprehension of migraine pathophysiology and mechanism of action for approved and emerging therapies. To address those gaps through accredited education, the current initiative aimed to develop a mixed reality program to incorporate into satellite symposia and online courses. Background Dynamic, physiological processes underlying migraine and its treatment are often explained through static illustration or linear animation. A mixed reality device provides 360-degree interactive views of neural processes and does not obscure the user’s view. By superimposing holographic images into the real world, opportunities for shared learning experiences are created among peers and between instructor-student groups. Design/Methods Faculty presented immersive, mixed reality visuals that depicted the neural dysfunction underlying migraine and mechanisms of action of therapeutic molecules. Information conveyed during the mixed reality experience was linked to relevant features of case(s) and a panel discussion. Data are reported based on pre- and post-tests and a post-presentation evaluation completed by HCP-learners. Results The mixed-reality experience was presented to 301 learners across 2 symposia; 83 individuals submitted evaluations. Of the total evaluations, 75% of participants were physicians, 45% headache specialists, and 23% general neurologists. To the statement that the mixed reality presentation enhanced their learning experience 85% agreed/strongly agreed; 95% agreed/strongly agreed that the activity met its learning objective to “describe the new concepts in migraine pathophysiology and MOA of new therapeutics”. Most comments were favorable, such as: “The HoloLens was extremely effective in helping me visualize the mechanism of action, which will help me retain the information longer,” though a few learners said they had trouble following the action or experienced motion sickness. Conclusions The interaction built into a mixed reality experience is designed to foster a deeper expertise of disease processes, how they impact patient burden, and can be used to individualize treatment. Authors/Disclosures PRESENTER No disclosure on file No disclosure on file