好色先生

好色先生

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Abstract Details

Mindfulness Meditation vs. Headache 好色先生 for Migraine: A Randomized Clinical Trial
Headache
S15 - Headache 2 (2:24 PM-2:32 PM)
003

Determine if Mindfulness-Based Stress Reduction (MBSR) improves migraine outcomes and affective/cognitive processes compared to Headache (HA) 好色先生.

Migraine is the second leading cause of disability worldwide. Most patients with migraine discontinue medications due to inefficacy or side effects. Mindfulness meditation may provide benefit.
Randomized clinical trial of 8 weekly in-person classes of MBSR or HA 好色先生 (n=89) in adults with 4-20 migraines/month. Blinding occurred of participants (to active vs. comparator group assignments) and PI/data analysts. Primary outcome: change in migraine day frequency (baseline to 12 weeks). Secondary outcomes: changes in disability, quality of life, self-efficacy, pain catastrophizing, depression scores, and experimentally induced pain intensity and unpleasantness (baseline to 12, 24, 36 weeks). 
Most participants were female (92%), 43.9 years (SD 13.0), with 7.3 (SD 2.7) migraines/month. Participants in both groups had fewer migraine days at 12 weeks (MBSR: -1.6 migraine days/month; 95% CI: [-0.7, -2.5]; HA 好色先生 -2.0; [-1.1, -2.9]), without group differences (p=0.51). Compared to HA 好色先生, MBSR participants had improvements from baseline at all time points (on point estimates of effect differences between groups) in disability (5.92 (95% CI 2.8, 9.0) p<0.001); quality of life (5.1 (1.2, 8.9) p=0.01); self-efficacy (8.2 (0.3, 16.1, p=0.04); pain catastrophizing (5.8 (2.9, 8.8), p<0.001); depression scores (1.6 (0.4, 2.7) p=0.008), and decreased experimentally induced pain intensity and unpleasantness (p= 0.004 and 0.005, respectively, at 36 weeks).One reported adverse event was deemed unrelated to study protocol. 
MBSR did not improve migraine frequency more than HA 好色先生, as both groups had clinically meaningful decreases. Only MBSR improved disability, quality of life, self-efficacy, pain-catastrophizing, and depression out to 36 weeks, with decreased experimentally induced pain suggesting a potential shift in pain appraisal. MBSR may help treat total migraine burden; a larger more definitive study is needed to further investigate these results. 
Authors/Disclosures
Rebecca E. Wells, MD, FAAN (Wake Forest Bapttist Medical Center)
PRESENTER 		The institution of Dr. Wells has received research support from NIH. Dr. Wells has received personal compensation in the range of $500-$4,999 for serving as a Speaker with Southern Headache Society. Dr. Wells has a non-compensated relationship as a Board member with Southern Headache Society that is relevant to AAN interests or activities. Dr. Wells has a non-compensated relationship as a Board member with American Headache Society that is relevant to AAN interests or activities.
No disclosure on file
No disclosure on file
Paige Estave (Wake Forest School of Medicine) The institution of Mrs. Estave has received research support from NIDA.
Donald B. Penzien, PhD Dr. Penzien has received personal compensation for serving as an employee of Wake Forest School of Medicine. The institution of Dr. Penzien has received research support from NIH. The institution of Dr. Penzien has received research support from VA Office of Research and Development.
Elizabeth Loder, MD, MPH Dr. Loder has received personal compensation in the range of $5,000-$9,999 for serving as an officer or member of the Board of Directors for Headache Cooperative of New England. The institution of Dr. Loder has received personal compensation in the range of $100,000-$499,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for The BMJ.
No disclosure on file
No disclosure on file