Abstract Details

Title Prevalence of Delirium and its Risk Factors in Hospitalized Patients with SARS-CoV-2 Infection

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) Behavioral and Cognitive Neurology Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 001

Objective To describe the prevalence and risk factors of delirium in hospitalized patients with SARS-CoV-2 infection.

Background Delirium is acute brain dysfunction that is seen among hospitalized patients with systemic illnesses. Since its emergence as a worldwide pandemic, infection with SARS-CoV-2 has been associated with variable degrees of delirium. However, the risk factors of delirium among these patients are yet to be determined.

Design/Methods This was a retrospective study of hospitalized patients with SARS-CoV-2 infection in one academic center from April through August 2020. Patient demographics, baseline comorbidities, and hospital complications were recorded. Univariable analyses were completed using Chi-Square, T-test, or Man-Whitney U Test. Binary logistic regression models were subsequently performed for the significant associations in the univariable analyses.

Results Data of 145 patients with confirmed SARS-CoV-2 infection were available (age 61.4±18.1 years, 41% female, and 29% African American). Delirium occurred in 33.8% of the patients. Patients with delirium were older, and had higher rates of hypertension, hyperlipidemia, diabetes mellitus, dementia, and psychiatric illness compared to those without delirium (P< 0.05). Furthermore, patients with delirium more frequently received supplemental oxygen, had lower PaO2/FiO2 ratio on admission, and higher levels of LDH, CRP and IL-6 compared to those without delirium (P<0.05). In logistic regression models, among the patients’ baseline characteristics, dementia was associated with greater odds of developing delirium (OR 4.25, 95% CI: 1.17-15.37, P=0.027). Additionally, among in-hospital complications, only cardiac complications and sepsis were independently associated with delirium in the logistic regression analysis (OR 9.02, 95% CI: 1.63-50.03, P=0.012, and OR 5.1 95%,CI: 1.88-13.84, P=0.001, respectively).

Conclusions Delirium is common among hospitalized patients with SARS-CoV-2 infection. Baseline dementia, in-hospital cardiac complications, and sepsis were independently associated with occurrence of delirium. Delirium in SARS-CoV-2 infection is likely related to the extent of systemic complications that are seen in these patients.

Authors/Disclosures
Sachi Gianchandani, MD (Stanford Health Care) PRESENTER	Dr. Gianchandani has nothing to disclose.
Sarah Addison	Ms. Addison has nothing to disclose.
Yousef Hannawi, MD (Ohio State University)	The institution of Dr. Hannawi has received research support from NIH.
Archana Hinduja, MD	Dr. Hinduja has nothing to disclose.

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