Abstract Details

Title Brain MRI volumetry in transient global amnesia

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) Behavioral and Cognitive Neurology Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 021

Objective Our objective is to measure the brain cortical volume in patients with transient global amnesia in contrast to healthy controls, hypothesizing that its reduction could be a contributing factor for the development of this syndrome.

Background Transient global amnesia (TGA) is a sudden onset anterograde amnesic disorder that typically resolves in less than 24 hours. One of the proposed physiopathological mechanisms leading to TGA is hippocampal ischemia due to venous insufficiency and jugular reflux. However, the high prevalence of jugular reflux in general population does not correlate with the low annual incidence of TGA.

Design/Methods We conducted a case-control study of patients diagnosed during the acute episode of TGA in our institution fulfilling the Hodges and Warlow diagnostic criteria between February-2015 and June-2020.
All subjects were studied in the first four months after the episode with brain MRI with T1 weighted volumetric sequence and T2 coronal high resolution sequence through the ASHS software (Automatic Segmentation of Hippocampal Subfields). We compared bilateral hippocampal and cortical volumes employing a linear regression model.

Results We included 20 subjects: 10 healthy controls and 10 patients with TGA. Median age of the TGA and control group were 68 years old (SD± 6) and 67 years old (SD± 8), respectively. We observed a significant reduction in cortical volume in the left CA2 region in the TGA patients (p=0.024) compared to the control group. The analysis of the remaining structures did not show statistically significant results.

Conclusions Patients with TGA have less cortical volume in the left CA2 subregion. Enlarging the total number of patients would let us determine if this is associated with an increased susceptibility for developing amnesic episodes after certain common triggers that provoke jugular reflux, compared to the general population.

Authors/Disclosures
Micaela Hernandez, MD (FLENI) PRESENTER	Dr. Hernandez has nothing to disclose.
Ismael Calandri, MD (FLENI)	Dr. Calandri has nothing to disclose.
	No disclosure on file
Lucas Alessandro, Sr., MD (FLENI)	Dr. Alessandro has nothing to disclose.
Ricardo F. Allegri, MD, PhD, FAAN (Institute for Neurological Research (FLENI))	Dr. Allegri has nothing to disclose.

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