We describe the case of a 26-year-old female, health care professional who was diagnosed with COVID19 infection manifested as self-resolved mild body aches, low grade fever and cough for a few days. Patient was evaluated at which time she did not require treatment; therefore, she was advised to self-isolate, which she did in a hotel for 14 days. Patient returned to work after 2 weeks of self-quarantine and resolution of her symptoms. While at work, patient had difficulty with concentration, inappropriate laughing episodes and previously recurring insomnia. She also displayed extreme anxiety towards work, dealing with COVID-19 positive patients, feeling of inadequacy, feeling guilty of spreading corona virus, crying spells, and panic attacks evidenced by palpitations, shortness of breath and restlessness. Patient was initially treated with Alprazolam, Trazodone and Escitalopram.  Subsequently, patient returned with auditory hallucinations where voices were telling her that she was killing patients and that her nurse license was fake. Patient also had persecutory delusions, therefore she was afraid she may kill someone and her license will be revoked. She displayed worsening symptoms of anxiety, rapid speech, and suicidal ideations; so an inpatient admission was warranted to rule out other organic causes of acute psychosis. Workup including infectious and metabolic panel, CTH, EEG and spinal tap to rule out encephalitis or other organic causes of her symptoms were unremarkable except for persisting positive COVID 19 PCR.  Consequently, she was diagnosed with acute psychosis and was successfully treated with Quetiapine, Escitalopram and Clonazepam.