Abstract Details

Title Impact of Delirium on Outcomes in Hospitalized Patients with SARS-CoV-2 Infection

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) Behavioral and Cognitive Neurology Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 002

Objective To describe the impact of delirium on outcomes in hospitalized patients with SARS-CoV-2 infection.

Background Delirium has been attributed to worsened outcomes of hospitalized patients with critical or systemic illness. SARS-CoV-2 infection has been associated with delirium. However, the impact of delirium on the outcome of these patients is yet to be determined.

Design/Methods This was a retrospective study of hospitalized patients with SARS-CoV-2 infection in one academic center from April through August 2020. Patients’ demographics, hospital complications, hospital length of stay, and discharge dispositions were recorded. Standard statistical univariable and multivariable models were performed to assess the associations of delirium with hospital outcomes.

Results Data of 145 patients with confirmed SARS-CoV-2 infection were available (age 61.4±18.1 years, 41% female, and 29% African American). Delirium occurred in 33.8% of patients. Patients with delirium had increased length of hospital stay, intensive care unit (ICU) stay, longer duration of mechanical ventilation and higher likelihood of discharge to hospice or death (P<0.05). In Linear regression analyses, longer hospital stay was significantly associated with delirium (B=0.377, 95% CI: 0.723-1.25), renal complications (B=0.203, 95% CI: 0.051-0.355), acute respiratory distress syndrome (ARDS) (B=0.152, 95% CI: 0.0069-0.308) and hyperlipidemia (B=-0.17, 95% CI: -0.327-0.009). Longer ICU stay was also significantly associated with delirium (B=0.39, 95% CI: 0.11-0.67). In ordered logistic regression, older age, ARDS, presence of renal complications, and delirium were independently associated with unfavorable discharge disposition to hospice or nursing home (B=0.046, 95% CI: 0.123-0.079; B=1.48, 95% CI: 0.538-2.441; B=0.902, 95% CI: 0.016-1.789; B=1.207, 95% CI: 0.227-2.188, respectively).

Conclusions Delirium in hospitalized patients with SARS-CoV-2 infection is associated with inferior hospital outcomes including longer hospital stay and higher likelihood of death or discharge to hospice care.

Authors/Disclosures
Sachi Gianchandani, MD (Stanford Health Care) PRESENTER	Dr. Gianchandani has nothing to disclose.
Sarah Addison	Ms. Addison has nothing to disclose.
Yousef Hannawi, MD (Ohio State University)	The institution of Dr. Hannawi has received research support from NIH.
Archana Hinduja, MD	Dr. Hinduja has nothing to disclose.

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