Abstract Details

Title Does Individuals’ Sex Affect Clinical, Neurological and Functional Outcomes After Acute Traumatic Spinal Cord Injury? Evidence from a Series of Propensity-Score Matched Cohort Studies.

Topic Neuro Trauma, Critical Care, and Sports Neurology

Presentation(s) Sports Neurology and Neuro Trauma Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 013

Objective This study examined the potential effects of sex on injury epidemiology, management and outcomes after acute traumatic SCI.

Background Few pre-clinical studies documented potential neuroprotective effects of estrogen and progesterone after SCI, but clinical evidence is lacking.

Design/Methods A series of propensity-score matched cohort studies was performed comparing subgroups of females in premenopause (age<40 years), females in perimenopause (41≥age≥50) and females in postmenopause (age>50), with the subgroups of males distributed similar age categories. Females were matched on a 1:1 ratio to males using the propensity score matching on age, co-morbidities, level and severity of SCI. Data from April/2014 to September/2019 were selected from a Canadian registry (RHSCIR). Females were compared with males regarding injury epidemiology, management in the acute care, and clinical, neurological and functional outcomes post-SCI.

Results

There were 1,245 females and 4,334 males that fulfilled the inclusion/exclusion and were considered during the propensity-score matching process. Among individuals younger than 40 years, females (n=320) more often were white (p=0.0268) and had SCI due to falls or transportation-related accidents (p=0.0014) than males (n=320). Both subgroups under 40 had comparable management except for females had more often surgical treatment (p=0.0326). There were no significant differences between females and males under 40 regarding outcomes. Among individuals between 40 and 50 years, females (n=133) were comparable to males (n=133) regarding the other baseline data, management, and outcomes. Among individuals older than 50 years, females (n=531) had more often fall-related SCIs than males (n=531). Females had shorter length of stay in the rehabilitation facilities than males (p=0.0205). There were no significant differences between the older subgroups of females and males regarding the other baseline data, management, and outcomes.

Conclusions Individuals’ sex was not a key determinant of the vast majority of clinical, neurological and functional outcomes following traumatic SCI, when data analyses were controlled for major potential confounders.

Authors/Disclosures
Julio C. Furlan, MD, PhD, MBA, MSc, FAAN (Lyndhurst Centre, Toronto Rehabilitation Institute; University of Toronto) PRESENTER	The institution of Dr. Furlan has received research support from Wings for Life Spinal Cord Research Foundation. The institution of Dr. Furlan has received research support from Craig H Neilsen Foundation. The institution of Dr. Furlan has received research support from Ontario Neurotrauma Foundation. The institution of Dr. Furlan has received research support from Cervical Spine Research Society. The institution of Dr. Furlan has received research support from J P Bickell Foundation. The institution of Dr. Furlan has received research support from Praxis Spinal Cord Institute. The institution of Dr. Furlan has received research support from Cervical Spine Research Society.
	No disclosure on file
	No disclosure on file

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