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Abstract Details

Seizure Control and Cognitive Outcomes in Patients with Encephalitis - A Retrospective Review
Autoimmune Neurology
P1 - Poster Session 1 (8:00 AM-9:00 AM)
9-005

Our aim was to assess the possible correlation of seizure burden and cognitive outcome at time of discharge in patients with encephalitis, stratified by etiology. 

 
Encephalitis is known to cause acute symptomatic seizures and at times post-encephalitic epilepsy. With discovery of new auto-antibodies, the diagnosis of encephalitis is gaining more awareness and with that it has become increasingly important to address the potential cognitive outcomes with prognosis in mind. 

We performed a retrospective analysis of a cohort of 12 patients with diagnosed encephalitis via clinical presentation, MRI, EEG and LP . Note that many of the presumed auto-immune/unknown cases had a negative LP. A descriptive analysis was performed on the subjects focusing on presentation, number of seizure medications required to achieve seizure control at time of discharge and cognitive outcome at discharge. Seizure control was defined as the absence of electrographic and clinical seizures for >24 hours by time of discharge. Cognitive outcomes were addressed as a comparison between cognition at presentation and cognitive status at time of discharge. 

 

 

 
Mean age 60.83 (SD 17.2) 8 (66%) male, 4 (33%) female. Of the cohort, 8 (66.66%) were autoimmune/unknown etiology, 3 (25%) infectious and 1 (8.33%) paraneoplastic. 37.50% of autoimmune, 66.67% of infectious and 100% of paraneoplastic etiological patients required anti-seizure medications at discharge. Cognitive outcomes at time of discharge : 62.50% of autoimmune/unknown, 33.30% of infectious and 100% of paraneoplastic patient's showed improvement. Of note, 62.5% of autoimmune/unknown patients were treated with steroids and immunotherapies. 
In our cohort, we found that etiologies of paraneoplastic and infectious causes of encephalitis were more commonly associated with development of seizures during the hospital course, requiring anti-seizure medications at time of discharge as compared to auto-immune/unknown. We also found that cognitive outcomes were more commonly unfavorable for infectious etiologies as compared to auto-immune and paraneoplastic. 
Authors/Disclosures
Omer W. Naveed, MD
PRESENTER 		Dr. Naveed has nothing to disclose.
Rizamarie Empeno, MD Dr. Empeno has nothing to disclose.
John Furey (Temple University Hospital) Mr. Furey has nothing to disclose.
Edward J. Gettings, DO (Temple University) Dr. Gettings has nothing to disclose.
Mercedes P. Jacobson, MD (Temple University) The institution of Dr. Jacobson has received research support from Engage. The institution of Dr. Jacobson has received research support from XENON. The institution of Dr. Jacobson has received research support from SK Life Sciences.