2016 Annual Meeting | Redefining Parkinson's Disease: Novel Approaches to Understanding Its Mechanisms and Developing Treatments

Date Saturday 04/16/16

Time 01:00 PM - 05:30 PM Add To Calendar

Session Format This program will be presented both in-person and online

On Demand This program is not expected to be available in the meeting's On Demand product.

Event Type Integrated Neuroscience

Director(s) Irene Litvan, MD, FAAN, Alberto J. Espay, MD, FAAN

Topic(s) Movement Disorders

Learning Objectives Participants should be able to recognize the increasing complexity of pathogenesis and pathologic spread in PD; describe the therapeutic approaches aimed at disease modification, with emphasis on immunotherapy aimed at alpha-synuclein propagation; and discuss the challenges and controversies associated current and evolving definitions of PD, which will shape therapeutic efforts in the coming years and decades.

CME Available 4.00 CME credits

Program Tracks Subspecialty in Focus

Recommended Audience Trainee, General Neurologist, Specialist Neurologist, Advanced Practice Provider

Teaching Styles Didactic, Interactive

Event Timeline
01:00 PM - 05:30 PM	Abstract	001 - Nicotinamide: A Key Player in the Developmental Origins of Parkinson’s Disease? Adrian Williams
01:00 PM - 05:30 PM	Abstract	002 - Genetic Variation Near the SNCA Gene Associates with Parkinson’s Disease Motor Endophenotype and Progression Christine Cooper, MD
01:00 PM - 05:30 PM	Abstract	003 - The Influence of Bacterial Amyloid on Alpha Synuclein (AS) Misfolding in the Rat Robert P. Friedland, MD, FAAN
01:00 PM - 05:30 PM	Abstract	004 - Trajectories of Prediagnostic Motor and Non-Motor Functioning in Parkinson Disease Sirwan K. Darweesh, MD, PhD
01:00 PM - 05:30 PM	Abstract	005 - Distinct Synuclein Seeds in Parkinson Disease and Multiple System Atrophy Tritia R. Yamasaki, MD, PhD, FAAN
01:00 PM - 05:30 PM	Abstract	006 - In Synucleinopathies, Elevated Ratios of Cysteinyl-Dopamine:3,4-Dihydroxyphenylacetic Acid (DOPAC) in Cerebrospinal Fluid are Associated Specifically with Parkinsonism David S. Goldstein, MD, PhD
01:00 PM - 05:30 PM	Abstract	007 - Antisense oligonucleotides to LRRK2 ameliorate alpha-synuclein pathology and behavioral deficit induced by pre-formed alpha-synuclein fibrils
01:00 PM - 05:30 PM	Abstract	008 - Nilotinib Improves Motor Skills, Cognition and Autonomic Function in Open-Label Phase I Clinical Trial in Parkinsons Disease with Dementia and Lewy Body Dementia Fernando L. Pagan, MD, FAAN
01:00 PM - 05:30 PM	Abstract	009 - Nilotinib Significantly Alters CSF Biomarkers and Increases Endogenous Dopamine in Open-Label Phase I Clinical Trial in Parkinsons Disease with Dementia and Lewy Body Dementia Charbel E. Moussa, PhD, MB
01:00 PM - 05:30 PM	Abstract	010 - MDS Clinical Diagnostic Criteria for Parkinson's Disease Ronald Postuma, MD
01:00 PM - 05:30 PM	Abstract	011 - MDS Research Criteria for Prodromal Pakrinson's Disease Ronald Postuma, MD
01:00 PM - 05:30 PM	Abstract	012 - EPI-743 Improves Motor Function and CNS Biomarkers in PD: Results from a Phase 2A Pilot Trial Theresa A. Zesiewicz, MD
01:00 PM - 05:30 PM	Abstract	013 - Activation of Chaperone-Mediated Autophagy Prevents Accumulation of Oligomeric Alpha-Synuclein in LRRK2 R1441G Knockin Mice of Parkinson’s Disease Shu Leong Ho, MD, FAAN
01:00 PM - 05:30 PM	Abstract	014 - Toward a New Biomarker of Parkinson’s Disease by Study of Alpha Synuclein on Upper Enteric System by Endoscopy Nadia B. Ben Ali, PhD
01:05 PM - 01:35 PM		Understanding the Complexity of Parkinson’s Disease Pathogenesis Anthony E. Lang, MD, FAAN
02:20 PM - 02:50 PM		Challenging the Centrality of Brainstem Lewy Bodies for PD Pathogenesis Glenda Halliday
03:35 PM - 04:15 PM		Break/Guided Poster Rounds
04:15 PM - 04:45 PM		Immunotherapy Against Alpha-Synuclein: Promises and Challenges Eliezer Masliah, MD

Faculty Disclosures
Robert P. Friedland, MD, FAAN	No disclosure on file
Irwin J. Kopin, MD	No disclosure on file
Anthony E. Lang, MD, FAAN	Dr. Lang has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for AbbVie, Amylyx, Aprinoia, Biogen, BioAdvance, Biohaven, BioVie, BlueRock, BMS, Denali, Janssen, Lilly, Pharma 2B, Sun Pharma, and UCB. Dr. Lang has received personal compensation in the range of $50,000-$99,999 for serving as an Expert Witness for medicolegal cases related to paraquat. The institution of Dr. Lang has received research support from AbbVie. Dr. Lang has received intellectual property interests from a discovery or technology relating to health care. Dr. Lang has received publishing royalties from a publication relating to health care.
Irene Litvan, MD, FAAN	Dr. Litvan has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Aprinoia. Dr. Litvan has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lundbeck. Dr. Litvan has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Frontiers in Neurology. Dr. Litvan has received personal compensation in the range of $50,000-$99,999 for serving as a Chief Editor with Frontiers in Neurology.
Clifton L. Gooch, MD, FAAN	Dr. Gooch has received publishing royalties from a publication relating to health care. Dr. Gooch has received publishing royalties from a publication relating to health care.
Theresa A. Zesiewicz, MD	Dr. Zesiewicz has received personal compensation for serving as an employee of Medscape. Dr. Zesiewicz has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Lexeo. Dr. Zesiewicz has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Steminent. Dr. Zesiewicz has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Larimar. Dr. Zesiewicz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biohaven. Dr. Zesiewicz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Zesiewicz has received intellectual property interests from a discovery or technology relating to health care. Dr. Zesiewicz has received intellectual property interests from a discovery or technology relating to health care. Dr. Zesiewicz has received intellectual property interests from a discovery or technology relating to health care.
Peter J. Koudstaal, MD	No disclosure on file
Albert Hofman, MD, PhD	No disclosure on file
Samir Belal, MD	No disclosure on file
Eliezer Masliah, MD	Dr. Masliah has nothing to disclose.
Marc Diamond, MD	The institution of Dr. Diamond has received research support from NIH. Dr. Diamond has received intellectual property interests from a discovery or technology relating to health care.
Cyrus P. Zabetian, MD	The institution of Dr. Zabetian has received research support from American Parkinson Disease Association. The institution of Dr. Zabetian has received research support from Department of Veterans Affairs. The institution of Dr. Zabetian has received research support from NIH. Dr. Zabetian has a non-compensated relationship as a Member, Scientific Advisory Council with Lewy Body Dementia Association that is relevant to AAN interests or activities.
Shu Leong Ho, MD, FAAN	No disclosure on file
Fernando L. Pagan, MD, FAAN	Dr. Pagan has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Acorda. Dr. Pagan has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Adamas. Dr. Pagan has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Amneal. Dr. Pagan has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Merz. Dr. Pagan has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Kyowa Kirin. Dr. Pagan has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sunovion. Dr. Pagan has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Teva. Dr. Pagan has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for US World Meds. Dr. Pagan has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Supernus. Dr. Pagan has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Abbvie. Dr. Pagan has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Acorda. Dr. Pagan has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Adamas. Dr. Pagan has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Amneal. Dr. Pagan has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Sunovion. Dr. Pagan has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Teva. Dr. Pagan has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Neurocrine. Dr. Pagan has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Sunovion. Dr. Pagan has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Supernus. Dr. Pagan has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Journal of Clinical Parkinsonism and related Disorders. Dr. Pagan has stock in Keiferx. The institution of Dr. Pagan has received research support from US World Meds. The institution of Dr. Pagan has received research support from Novartis.
John Q. Trojanowski, MD, PhD	Dr. Trojanowski has nothing to disclose.
Alberto J. Espay, MD, FAAN	Dr. Espay has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Tanabe Pharma America (formerly, Neuroderm). Dr. Espay has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Avion. Dr. Espay has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Amneal. Dr. Espay has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Acadia. Dr. Espay has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Acorda. Dr. Espay has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Kyowa Kirin. Dr. Espay has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sunovion. Dr. Espay has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Herantis Pharma. Dr. Espay has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Supernus (formerly USWorldMeds). Dr. Espay has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Acadia. Dr. Espay has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Synaps Dx. Dr. Espay has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Bial. Dr. Espay has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for NeuroDiagnostics, Inc (SYNAPS Dx). Dr. Espay has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Intrance Medical Systems, Inc.. Dr. Espay has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Merz. Dr. Espay has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Praxis Precision Medicines. Dr. Espay has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Citrus Health. Dr. Espay has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AskBio. The institution of Dr. Espay has received research support from NIH. The institution of Dr. Espay has received research support from Michael J Fox Foundation for Parkinson's Research. Dr. Espay has received intellectual property interests from a discovery or technology relating to health care. Dr. Espay has received publishing royalties from a publication relating to health care. Dr. Espay has received publishing royalties from a publication relating to health care. Dr. Espay has received publishing royalties from a publication relating to health care.
Paul T. Kotzbauer, MD, PhD	No disclosure on file
David S. Goldstein, MD, PhD	Dr. Goldstein has received publishing royalties from a publication relating to health care.
Ronald Postuma, MD	Dr. Postuma has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Roche, Biogen, Takeda, Theranexus, GE, Jazz, Curasen, Paladin, Inception Sciences, Phytopharmics, Vaxxinity, Merck. Dr. Postuma has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen/Partners. The institution of Dr. Postuma has received research support from CIHR, Weston Foundation, Webster Foundation, Roche, MJFF, Parkinson Canada, FRSQ, NIH.
Kelly Sullivan, PhD	Dr. Sullivan has received intellectual property interests from a discovery or technology relating to health care.
Alice Chen-Plotkin, MD	Dr. Chen-Plotkin has received intellectual property interests from a discovery or technology relating to health care.
	No disclosure on file
Mohammad Ikram	The institution of Mohammad Ikram has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BioGen Inc.
Christine Cooper, MD	Dr. Cooper has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Acorda. Dr. Cooper has received research support from NIH. Dr. Cooper has received research support from Ralph H Johnson VA Medical Center.
Daniel Weintraub	Daniel Weintraub has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Clintrex. Daniel Weintraub has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai. Daniel Weintraub has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Daniel Weintraub has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sage. Daniel Weintraub has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Scion. Daniel Weintraub has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Signant. Daniel Weintraub has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sunovion. Daniel Weintraub has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Modality.ai. Daniel Weintraub has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cerevel. Daniel Weintraub has received personal compensation in the range of $500-$4,999 for serving as a Consultant for CuraSen. Daniel Weintraub has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Takeda. Daniel Weintraub has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Boehringer Ingelheim. Daniel Weintraub has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Daniel Weintraub has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Acadia. Daniel Weintraub has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Movement Disorder Society. The institution of Daniel Weintraub has received research support from NIH. The institution of Daniel Weintraub has received research support from Fox Foundation. The institution of Daniel Weintraub has received research support from IPMDS. Daniel Weintraub has received intellectual property interests from a discovery or technology relating to health care.
Sean Rogers, MD, PhD	No disclosure on file
Tritia R. Yamasaki, MD, PhD, FAAN	The institution of Dr. Yamasaki has received research support from Veteran's Affairs. The institution of an immediate family member of Dr. Yamasaki has received research support from Dept of Energy.
Brandon Holmes, MD, PhD	No disclosure on file
Charbel E. Moussa, PhD, MB	Dr. Moussa has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for KeifeRX LLC. Dr. Moussa has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sun Pharmaceuticals Research Industry. Dr. Moussa has received stock or an ownership interest from Orphan Therapeutics. The institution of Dr. Moussa has received research support from NIA. The institution of Dr. Moussa has received research support from Sun Pharmaceuticals Research Industry. The institution of Dr. Moussa has received research support from Alzheimer's Association . Dr. Moussa has received intellectual property interests from a discovery or technology relating to health care. Dr. Moussa has received intellectual property interests from a discovery or technology relating to health care. Dr. Moussa has received publishing royalties from a publication relating to health care. Dr. Moussa has received personal compensation in the range of $500-$4,999 for serving as a Grant reviewer with DG Information Technology. Dr. Moussa has received personal compensation in the range of $0-$499 for serving as a Peer Reviews with National Institutes of Health.
Ramsey A. Falconer, MD, FAAN	Dr. Falconer has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for Abbott. Dr. Falconer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Abbvie. Dr. Falconer has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for Amneal. Dr. Falconer has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for GE Health. Dr. Falconer has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Acorda. Dr. Falconer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Kyowa Kirin. Dr. Falconer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Neurocrine. Dr. Falconer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Supernus. Dr. Falconer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Sunovion. Dr. Falconer has received personal compensation in the range of $50,000-$99,999 for serving as an Expert Witness for Federal Trade Comission (FTC). Dr. Falconer has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Justice Department.
Israt Jahan, MD	No disclosure on file
Reversa R. Mills-Joseph, MD	Dr. Mills has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Kyowa Kirin, Inc. Dr. Mills has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Abbvie.
Shirley Y. Pang	Dr. Pang has nothing to disclose.
Adrian Williams	No disclosure on file
Ellen Valadez, MD	No disclosure on file
Yasar A. Torres-Yaghi, MD	Dr. Torres-Yaghi has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Acorda. Dr. Torres-Yaghi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Abbvie. Dr. Torres-Yaghi has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Amneal. Dr. Torres-Yaghi has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Abbott. Dr. Torres-Yaghi has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Kyowa Kirin. Dr. Torres-Yaghi has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Teva. Dr. Torres-Yaghi has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Sunovion .
Sirwan K. Darweesh, MD, PhD	No disclosure on file
Yosef Berlyand	No disclosure on file
Tracy M. Jones, ARNP	No disclosure on file
Nadia B. Ben Ali, PhD	No disclosure on file
Glenda Halliday	No disclosure on file
Eric Swayze, PhD	No disclosure on file
Matthew Klein	Matthew Klein has received personal compensation for serving as an employee of PTC Therapeutics. Matthew Klein has stock in PTC Therapeutics. Matthew Klein has received publishing royalties from a publication relating to health care.

��ɫ��

��ɫ��