2016 Annual Meeting | Amyloid and Beyond: From Bench to Bedside

Date Wednesday 04/20/16

Time 01:00 PM - 05:30 PM Add To Calendar

Session Format This program will be presented both in-person and online

On Demand This program is not expected to be available in the meeting's On Demand product.

Event Type Integrated Neuroscience

Director(s) Liana Apostolova, MD, FAAN, David S. Knopman, MD, FAAN

Topic(s) Aging, Dementia, and Behavioral Neurology

Learning Objectives Gain knowledge of the role of amyloid species in normal aging and AD
Understand the role new imaging methods play in neurodegenerative diseases
Gain knowledge of the specific imaging biomarker signatures of the major classes of neurodegenerative diseases
Understand how biomarkers can be used in conjunction with clinical findings to refine the differential diagnosis

CME Available No CME available

Program Tracks Subspecialty in Focus

Event Timeline
01:00 PM - 01:10 PM		Introduction
01:00 PM - 05:30 PM	Abstract	001 - FERMT2 Is Associated with Brain Amyloidosis in Cognitively Normal and Mild Cognitive Impairment Subjects Naira Goukasian
01:00 PM - 05:30 PM	Abstract	002 - Multimorbidity and Neuroimaging Biomarkers Among Cognitively Normal Persons Maria Vassilaki, MD, PhD
01:00 PM - 05:30 PM	Abstract	003 - Differences in 11C-PIB-PET Imaging Patterns Between Alzheimer’s Disease Patients with and without Cerebral Cortical/Subcortical Microbleeds Yuichi Hayashi
01:00 PM - 05:30 PM	Abstract	004 - Literature Review of Genetic Disorders with tau Pathology Pawel Tacik, MD
01:00 PM - 05:30 PM	Abstract	005 - Imaging tau Pathology In Vivo in AD and FTLD Spectrum Tauopathies with [18F] AV1451 PET Bradford Dickerson, MD, FAAN
01:00 PM - 05:30 PM	Abstract	006 - Amyloid-β and Hyperphosphorylated tau Synergy Drives Metabolic Decline in Preclinical Alzheimer’s Disease Tharick A. Pascoal, Sr., MD, PhD
01:00 PM - 05:30 PM	Abstract	007 - Prevalence of Amyloid Pathology in Primary Progressive Aphasia Variants: A Systematic Review and Meta-Analysis David Bergeron
01:00 PM - 05:30 PM	Abstract	008 - Rapidly Progressive Alzheimer’s Disease in Two Distinct Autopsy Cohorts Jagan Pillai, MD, PhD, FAAN
01:00 PM - 05:30 PM	Abstract	009 - Biomarker Confirmed Alzheimer’s Disease Presenting as Amnestic, Aphasic, and Visual Variants: Hippocampal Volume Comparison Alissa Butts
01:00 PM - 05:30 PM	Abstract	010 - Cascading Network Failure across the Alzheimer’s Disease Spectrum David T. Jones, MD
01:00 PM - 05:30 PM	Abstract	011 - Behavioral Correlates of Cognitive Decline in Normal Aging and Prodromal Alzheimer’s Disease Naira Goukasian
01:00 PM - 05:30 PM	Abstract	012 - Effect of Brain Amyloidosis on the Emergence of Neuropsychiatric Behaviors in MCI over Time Liana Apostolova, MD, FAAN
01:00 PM - 05:30 PM	Abstract	013 - Sensitivity, Specificity and Reliability of Three Pathological Criteria for Alzheimer’s Disease Alexis M. Steinberg, MD
01:10 PM - 01:50 PM		The Many Faces of the Amyloid-beta Protein in Aging and Alzheimer's Disease Karen H. Ashe, MD, PhD
02:20 PM - 03:00 PM		Current State of Tau PET Imaging Bradford Dickerson, MD, FAAN
03:30 PM - 04:15 PM		Break/Guided Poster Tour
04:15 PM - 04:55 PM		PET Imaging of Alzheimer's Disease Variants and non-Alzheimer's Disease Dementias Robert Laforce, Jr., MD, PhD
05:10 PM - 05:30 PM		Conclusion

Faculty Disclosures
Karen H. Ashe, MD, PhD	No disclosure on file
Robert Laforce, Jr., MD, PhD	Dr. Laforce has nothing to disclose.
Liana Apostolova, MD, FAAN	Dr. Apostolova has received personal compensation in the range of $500-$4,999 for serving as a Consultant for NIH. Dr. Apostolova has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Apostolova has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Apostolova has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai. Dr. Apostolova has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech. Dr. Apostolova has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Apostolova has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech. Dr. Apostolova has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Alzheimer Association. An immediate family member of Dr. Apostolova has stock in Cassava Neurosciences. The institution of Dr. Apostolova has received research support from Roche Diagnostics. The institution of Dr. Apostolova has received research support from NIA. The institution of Dr. Apostolova has received research support from Alzheimer Association. The institution of Dr. Apostolova has received research support from AVID radiopharmaceuticals. The institution of Dr. Apostolova has received research support from Life Molecular Imaging.
David S. Knopman, MD, FAAN	Dr. Knopman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for DIAN TU study. The institution of Dr. Knopman has received research support from NIH.
Bradford Dickerson, MD, FAAN	Dr. Dickerson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Dickerson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Acadia. Dr. Dickerson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Arkuda. Dr. Dickerson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai. Dr. Dickerson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Lantheus. Dr. Dickerson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Lilly. Dr. Dickerson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Dickerson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novo Nordisk. Dr. Dickerson has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Dr. Dickerson has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Arkuda. Dr. Dickerson has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Acadia. Dr. Dickerson has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lilly. Dr. Dickerson has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Dickerson has received publishing royalties from a publication relating to health care. Dr. Dickerson has received publishing royalties from a publication relating to health care.
Ronald C. Petersen, MD, PhD, FAAN	Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly and Co.. Dr. Petersen has received personal compensation in the range of $0-$499 for serving as a Consultant for Eisai, Inc.. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novo Nordisk. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has a non-compensated relationship as a Board of Directors with American Brain Foundation that is relevant to AAN interests or activities.
Dennis W. Dickson, MD	Dr. Dickson has nothing to disclose.
Keith A. Josephs, Jr., MD, FAAN	Dr. Josephs has nothing to disclose.
Keith A. Johnson, MD	Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AC Immune. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Shionogi. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Prothena. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for NervGen. An immediate family member of Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Oligomerix. Dr. Johnson has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AC Immune. The institution of Dr. Johnson has received research support from National Institute on Aging. The institution of an immediate family member of Dr. Johnson has received research support from Alzheimer's Association. The institution of an immediate family member of Dr. Johnson has received research support from Eli Lilly and Co. The institution of Dr. Johnson has received research support from Eisai. The institution of an immediate family member of Dr. Johnson has received research support from Eisai.
Serge G. Gauthier, MD	Dr. Gauthier has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for TauRx . Dr. Gauthier has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lilly Canada . Dr. Gauthier has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai . Dr. Gauthier has received personal compensation in the range of $50,000-$99,999 for serving on a Scientific Advisory or Data Safety Monitoring board for ENIGMA USA. Dr. Gauthier has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AmyriAD. Dr. Gauthier has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Medesis. Dr. Gauthier has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Alzheon. Dr. Gauthier has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Karuna. Dr. Gauthier has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Otsuka . Dr. Gauthier has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for NovoNordisk. Dr. Gauthier has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Biogen Canada. Dr. Gauthier has received personal compensation in the range of $5,000-$9,999 for serving as an officer or member of the Board of Directors for Sharon Francis Foundation . Dr. Gauthier has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JPAD. Dr. Gauthier has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Lundbeck Foundation . Dr. Gauthier has received publishing royalties from a publication relating to health care.
Michelle M. Mielke, PhD	Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for LabCorp. Dr. Mielke has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Roche. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Siemens Healthineers. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sunbird Bio. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai. Dr. Mielke has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Roche. Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novo Nordisk.
	No disclosure on file
Eric M. McDade, DO	Dr. McDade has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi. Dr. McDade has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. McDade has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alector. Dr. McDade has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alzamend. Dr. McDade has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Fondation Alzheimer. Dr. McDade has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alnylam. Dr. McDade has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Dr. McDade has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Ionis. The institution of Dr. McDade has received research support from NIA. The institution of Dr. McDade has received research support from Eli Lilly. The institution of Dr. McDade has received research support from Hoffman-La Roche. The institution of Dr. McDade has received research support from Eisai. The institution of Dr. McDade has received research support from Eisai. Dr. McDade has received intellectual property interests from a discovery or technology relating to health care. Dr. McDade has received personal compensation in the range of $500-$4,999 for serving as a Advisory Board Member with Fondation Alzheimer.
Michael W. Weiner, MD	No disclosure on file
Jonathan Graff-Radford, MD, FAAN	Dr. Graff-Radford has received personal compensation for serving as an employee of Mayo Clinic. Dr. Graff-Radford has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for NINDS/NIH. Dr. Graff-Radford has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JAMA Neurology. The institution of Dr. Graff-Radford has received research support from NIH. The institution of Dr. Graff-Radford has received research support from Eisai. The institution of Dr. Graff-Radford has received research support from Cognition therapeutics.
Takashi Inuzuka, MD, FAAN	No disclosure on file
Jagan Pillai, MD, PhD, FAAN	Dr. Pillai has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Springer Nature. Dr. Pillai has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Current Treatment Options in Neurology. The institution of Dr. Pillai has received research support from Alzheimer's Association. The institution of Dr. Pillai has received research support from Keep Memory Alive Foundation . The institution of Dr. Pillai has received research support from NIA. Dr. Pillai has received personal compensation in the range of $500-$4,999 for serving as a Reviewer with DOD. Dr. Pillai has received personal compensation in the range of $500-$4,999 for serving as a Reviewer with RGC Hong kong.
Scott Przybelski	Scott Przybelski has nothing to disclose.
Daniel A. Drubach, MD, FAAN	No disclosure on file
Yonas E. Geda, MD	The institution of Dr. Geda has received research support from NIH.
Rosebud O. Roberts, MD	No disclosure on file
James B. Leverenz, MD, FAAN	Dr. Leverenz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Acadia. Dr. Leverenz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Leverenz has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai.
Bradley F. Boeve, MD, FAAN	Dr. Boeve has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Rainwater Charitable Foundation. The institution of Dr. Boeve has received research support from Alector. The institution of Dr. Boeve has received research support from EIP Pharma. The institution of Dr. Boeve has received research support from Transposon. The institution of Dr. Boeve has received research support from Cognition Therapeutics. Dr. Boeve has received publishing royalties from a publication relating to health care.
Prashanthi Vemuri, PhD	The institution of Dr. Vemuri has received research support from NIH.
Jeffery Gunter	The institution of Jeffery Gunter has received research support from NIH. Jeffery Gunter has received intellectual property interests from a discovery or technology relating to health care.
Jeremiah Aakre, MPH	Mr. Aakre has nothing to disclose.
Clifford R. Jack, Jr., MD	The institution of Dr. Jack has received research support from NIH. The institution of Dr. Jack has received research support from Alexander Family Alzheimer's Disease Research Professorship of the Mayo Clinic.
Yuichi Hayashi	Yuichi Hayashi has nothing to disclose.
Sarah Berman, MD	The institution of Dr. Berman has received research support from NIH.
Anthony Polazzo	No disclosure on file
Mary M. Machulda, PhD	The institution of Dr. Machulda has received research support from NIH.
Oscar L. Lopez, MD, FAAN	Dr. Lopez has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Acumen.
James T. Becker, PhD	No disclosure on file
John M. Ringman, MD, FAAN	The institution of Dr. Ringman has received research support from Avid Pharmaceuticals. The institution of Dr. Ringman has received research support from AltaMed. The institution of Dr. Ringman has received research support from CurePSP.
William E. Klunk, MD, PhD	No disclosure on file
Pedro Rosa Neto, MD, PhD	Dr. Rosa Neto has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novo Nordisk.
Alexis M. Steinberg, MD	The institution of Dr. Steinberg has received research support from University of Pittsburgh Clinical and Translational Institute (CTSI).
Maria Vassilaki, MD, PhD	Dr. Vassilaki has stock in Abbott Laboratories. Dr. Vassilaki has stock in Johnson and Johnson. Dr. Vassilaki has stock in Medtronic. Dr. Vassilaki has stock in Amgen. Dr. Vassilaki has stock in AbbVie. Dr. Vassilaki has stock in Merck. The institution of Dr. Vassilaki has received research support from NIH. The institution of Dr. Vassilaki has received research support from European Union/ St. Anne's University Hospital Brno, Czech Republic. The institution of an immediate family member of Dr. Vassilaki has received research support from Avobis Bio, LLC.
Robert A. Sweet	Robert A. Sweet has nothing to disclose.
Scott McGinnis, MD	Dr. McGinnis has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai.
Rosa Rademakers, PhD	Rosa Rademakers, PhD has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Mayo Clinic. Rosa Rademakers, PhD has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Arkuda Therapeutics. Rosa Rademakers, PhD has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Alzheimer Fondation. Rosa Rademakers, PhD has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Kisick Family Foundation (FTD grant program). The institution of Rosa Rademakers, PhD has received research support from NIH. The institution of Rosa Rademakers, PhD has received research support from DOD. The institution of Rosa Rademakers, PhD has received research support from Flanders Institute for Biotechnology (VIB). The institution of Rosa Rademakers, PhD has received research support from Flanders Funds for Scientific Research.
Brian Appleby, MD	Dr. Appleby has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Acadia. Dr. Appleby has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Ionis. Dr. Appleby has received personal compensation in the range of $0-$499 for serving as a Consultant for Sangamo. The institution of Dr. Appleby has received research support from CJD Foundation. The institution of Dr. Appleby has received research support from Ionis. The institution of Dr. Appleby has received research support from Alector. The institution of Dr. Appleby has received research support from CDC. The institution of Dr. Appleby has received research support from NIH. Dr. Appleby has received publishing royalties from a publication relating to health care. Dr. Appleby has received publishing royalties from a publication relating to health care.
Chenjie Xia, MD	No disclosure on file
David T. Jones, MD	Dr. Jones has received intellectual property interests from a discovery or technology relating to health care.
Nobuaki Yoshikura, MD, PhD	Dr. Yoshikura has nothing to disclose.
Val J. Lowe, MD	Dr. Lowe has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for AVID Radiopharmaceutical. Dr. Lowe has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai Inc. The institution of Dr. Lowe has received research support from AVID Radiopharmaceuticals.
Jennifer Whitwell, PhD	Dr. Whitwell has nothing to disclose.
Jiri G. Safar, MD	No disclosure on file
Naira Goukasian	No disclosure on file
Walter Kremers	The institution of Walter Kremers has received research support from NIH. The institution of an immediate family member of Walter Kremers has received research support from NIH.
David Bergeron	No disclosure on file
Tharick A. Pascoal, Sr., MD, PhD	Dr. Pascoal has nothing to disclose.
Alissa Butts	No disclosure on file
Megan Quimby	Ms. Quimby has nothing to disclose.
Pawel Tacik, MD	No disclosure on file
Zbigniew K. Wszolek, MD, FAAN	Dr. Wszolek has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Polish Neurological Society/Via Medica.

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