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2006 Annual Meeting | Genetics of Motor Neuron Disease

Wednesday 04/05/06
02:00 PM - 03:30 PM Add To Calendar
This program will be presented both in-person and online
This program is not expected to be available in the meeting's On Demand product.
Integrated Neuroscience
Anterior Horn, Behavioral Neurology, Neurogenetics and Gene Therapy
No CME available
Event Timeline
02:00 PM - 03:30 PM Refreshments
02:00 PM - 03:30 PM Abstract 001 - Age of SOD1 A4V Mutation Causing ALS and Founder Effect
02:00 PM - 03:30 PM Abstract 001 - Repressible and Restricted or Unrestricted Spatial Expression of Cu/Zn Superoxide Dismutase (SOD1) and Luciferase (luc) in Mice
02:00 PM - 03:30 PM Abstract 002 - Paraoxonase Gene Cluster Is Associated with Sporadic Amyotrophic Lateral Sclerosis (SALS)
02:00 PM - 03:30 PM Abstract 002 - Mutations in the Dynactin Gene and Amyotrophic Lateral Sclerosis
02:00 PM - 03:30 PM Abstract 003 - Paraoxonase-1 Gly192Arg and Leu55Met and Paraoxonase-2 Ser311Cys Polymorphisms and Risk for Sporadic Amyotrophic Lateral Sclerosis
02:00 PM - 03:30 PM Abstract 003 - Angiogenin Mutations Segregate with Familial and 'Sporadic' ALS
02:00 PM - 03:30 PM Abstract 004 - Selective Gene Ablation of Mutant SOD1 in Microglia Significantly Slows Disease Progression of ALS
02:00 PM - 03:30 PM Abstract 004 - Analysis of the Cu/Zn Gene in a Catalan ALS Population. Should All Sporadic ALS Cases Also Be Screened for SOD1?
02:00 PM - 03:30 PM Abstract 005 - Intravenous Plasmid DNA-Mediated Gene Transfer of IGF-1 Is Therapeutic for SOD1 Mouse Model of ALS
02:00 PM - 03:30 PM Abstract 005 - Increased Exon Exclusion Caused by a Novel Mutation in the HEXB Gene Affecting a Splicing Enhancer (ESE) Binding Motif Results in the Sandhoff' Motor Neuron Phenotype
02:00 PM - 03:30 PM Abstract 006 - siRNA Mediated Interference of Motoneuron Death Triggered by Fas in SOD1 G93A ALS Mouse Model
02:00 PM - 03:30 PM Abstract 006 - Alternative Splicing of [italic]SMN2[/italic] Exon7 Modeled in Mice To Create Hypomorphic [italic]Smn[/italic] Alleles That Present with Spinal Muscular Atrophy (SMA)
02:00 PM - 03:30 PM Abstract 007 - Eight Novel Mutations in SPG4 Gene in a Large Sample of Patients with Hereditary Spastic Paraplegia
02:00 PM - 03:30 PM Abstract 008 - Screening Mutations in the CHMP2B Gene in Familiar Amyotrophic Lateral Sclerosis with Frontotemporal Dementia (ALS/FTD)
02:00 PM - 03:30 PM Abstract 009 - FTD with Ubiquinated Inclusions: Clinical and Neuropathological Variation Associated with a Common Haplotype at Chromosome 17q21
02:00 PM - 03:30 PM Abstract 010 - Acetylcholinesterase Antisense Oligonucleotides (EN101) as a Novel Treatment Strategy for ALS: A Mouse Model Study
02:00 PM - 03:30 PM Abstract 011 - Pre-Clinical Validation of a Multiplex Real-Time RT-PCR Assay To Quantify SMN Transcripts in Whole Blood Samples from SMA Patients
Faculty Disclosures
Oded Abramsky, MD, PhD, FAAN No disclosure on file
Zohar Argov, MD No disclosure on file
Claude Belanger, MD No disclosure on file
Nereo Bresolin, DR No disclosure on file
Robert H. Brown, Jr., MD, DPhil Dr. Brown has received personal compensation for serving as an employee of ApicBio. Dr. Brown has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for ApicBio. Dr. Brown has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Warren Alpert Foundation. Dr. Brown has stock in ApicBio. Dr. Brown has stock in Amylx. Dr. Brown has stock in Imstar. The institution of Dr. Brown has received research support from Angel Fund for ALS Research. The institution of Dr. Brown has received research support from ALS Association. The institution of Dr. Brown has received research support from ALSOne. The institution of Dr. Brown has received research support from NINDS. The institution of Dr. Brown has received research support from ALS Finding A Cure. Dr. Brown has received publishing royalties from a publication relating to health care.
Howard Feldman, MD, FAAN The institution of Dr. Feldman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Arrowhead Pharmaceuticals. The institution of Dr. Feldman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novo Nordisk. The institution of Dr. Feldman has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Janssen Research & Development LLC. The institution of Dr. Feldman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche/Banner/API. The institution of Dr. Feldman has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Tau Consortium. The institution of Dr. Feldman has received research support from US National Institute of Health NIH/NIA. The institution of Dr. Feldman has received research support from US National Institute of Health NIH/NIA. The institution of Dr. Feldman has received research support from Vivoryon Therapeutics. The institution of Dr. Feldman has received research support from US National Institute of Health NIH/NIA. The institution of Dr. Feldman has received research support from US National Institute of Health NIH/NIA. The institution of Dr. Feldman has received research support from LuMind Foundation. The institution of Dr. Feldman has received research support from US National Institute of Health NIH/NIA. The institution of Dr. Feldman has received research support from Biohaven Pharmaceuticals. The institution of Dr. Feldman has received research support from UC San Diego School of Medicine Brain Health Support Program & Sanford Institute for Empathy and Compassion. The institution of Dr. Feldman has received research support from US National Institute of Health NIH/NIA. The institution of Dr. Feldman has received research support from US National Institute of Health NIH/NIA. Dr. Feldman has received intellectual property interests from a discovery or technology relating to health care. Dr. Feldman has a non-compensated relationship as a Medical Advisory Council with Association for Frontotemporal Degeneration (AFTD) that is relevant to AAN interests or activities. Dr. Feldman has a non-compensated relationship as a International Scientific Advisory Board with Translating Research in Elder Care (TREC) that is relevant to AAN interests or activities.
Kenneth H. Fischbeck, MD, FAAN Dr. Fischbeck has received research support from NINDS/NIH. Dr. Fischbeck has received intellectual property interests from a discovery or technology relating to health care. Dr. Fischbeck has a non-compensated relationship as a Scientific Review Board member with Kennedy's Disease Association that is relevant to AAN interests or activities. Dr. Fischbeck has a non-compensated relationship as a Scientific Council member with Association Francaise contre les Myopathies that is relevant to AAN interests or activities. Dr. Fischbeck has a non-compensated relationship as a Independent Review Committee member with Target ALS that is relevant to AAN interests or activities. Dr. Fischbeck has a non-compensated relationship as a Scientific Advisory Board member, Musculoskeletal Diseases with Novartis that is relevant to AAN interests or activities. Dr. Fischbeck has a non-compensated relationship as a Senior Clinical Consultant with n-Lorem Foundation that is relevant to AAN interests or activities. Dr. Fischbeck has a non-compensated relationship as a Scientific Advisory Committee member with Stanford GNE myopathy program that is relevant to AAN interests or activities. Dr. Fischbeck has a non-compensated relationship as a Scientific Advisory Board member with Hereditary Disease Foundation that is relevant to AAN interests or activities. Dr. Fischbeck has a non-compensated relationship as a Scientific Advisory Board member with Packard Center for ALS Research that is relevant to AAN interests or activities. Dr. Fischbeck has a non-compensated relationship as a Scientific Advisory Board member with Huntington's Disease Society of America that is relevant to AAN interests or activities. Dr. Fischbeck has a non-compensated relationship as a TACT review panel member with TREAT-NMD that is relevant to AAN interests or activities.
Scott L. Heller, MD No disclosure on file
Bonnie E. Levin, PhD No disclosure on file
Andrea Martinuzzi, MD, PhD, FAAN No disclosure on file
Victor H. Patterson, MD No disclosure on file
Raymond P. Roos, MD, FAAN Dr. Roos has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for MedLink. Dr. Roos has stock in Amazon. Dr. Roos has stock in Amgen. Dr. Roos has stock in Apple. Dr. Roos has stock in Cigna. Dr. Roos has stock in IBM. Dr. Roos has stock in Ionis. Dr. Roos has stock in Pfizer. Dr. Roos has received research support from Lohengrin Foundation.
Teepu Siddique, MD, FAAN No disclosure on file
Robert L. Sufit, MD No disclosure on file
Orla Hardiman, MD, FRCPI, FAAN Dr. Hardiman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Wave Pharmaceuticals. Dr. Hardiman has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Cytokinetics . Dr. Hardiman has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Hardiman has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Taylor and Francis. The institution of Dr. Hardiman has received research support from Science Foundation Ireland. The institution of Dr. Hardiman has received research support from HRB.
Massimo Pandolfo, MD, FAAN Dr. Pandolfo has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Design Therapeutics . Dr. Pandolfo has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. Dr. Pandolfo has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Solid Bio. Dr. Pandolfo has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Neurocrine. Dr. Pandolfo has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Design Therapeutics. Dr. Pandolfo has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Larimar. Dr. Pandolfo has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neurology Genetics. Dr. Pandolfo has stock in Voyager Therapeutics. The institution of Dr. Pandolfo has received research support from Freidreich Ataxaia Research Alliance. Dr. Pandolfo has a non-compensated relationship as a Scientific Advisory Board with Friedreich Ataxia Research Alliance that is relevant to AAN interests or activities. Dr. Pandolfo has a non-compensated relationship as a Member-Meeting Management Committee with AAN that is relevant to AAN interests or activities.
Albert C. Ludolph, MD Dr. Ludolph has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Ludolph has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Ludolph has received personal compensation in the range of $0-$499 for serving as a Consultant for FundaMental Pharma . Dr. Ludolph has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Lilly. Dr. Ludolph has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Zambon . Dr. Ludolph has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Ludolph has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche Pharma. Dr. Ludolph has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Ludolph has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alector. Dr. Ludolph has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Amylyx. Dr. Ludolph has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biologix FZCo.. Dr. Ludolph has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Dr. Ludolph has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Teva. Dr. Ludolph has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Dr. Ludolph has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Dr. Ludolph has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Zambon.
Giovanni Meola, MD, FAAN No disclosure on file
Hubert Kwiecinski, MD, PhD No disclosure on file
Cinzia Gellera, MD No disclosure on file
Carlayne E. Jackson, MD, FAAN Dr. Jackson has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Mitsubishi Tanabe Pharma America. Dr. Jackson has received personal compensation in the range of $100,000-$499,999 for serving as an officer or member of the Board of Directors for AAN. The institution of Dr. Jackson has received research support from NIH. The institution of Dr. Jackson has received research support from Massachussetts General Hospital.
Enzo Ricci, MD No disclosure on file
Pietro Tonali, MD No disclosure on file
Robert J. Swingler, MD No disclosure on file
Kathryn J. Swoboda, MD Dr. Swoboda has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Swoboda has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. The institution of Dr. Swoboda has received research support from Biogen.
Ian R.A. Mackenzie, MD, FRCP No disclosure on file
Gyula Acsadi, MD, FAAN Dr. Acsadi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Dr. Acsadi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Avexis. Dr. Acsadi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Serepta. Dr. Acsadi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Acsadi has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen.
Maria D'Angelo, MD No disclosure on file
Gabriella Silvestri, MD No disclosure on file
Andrzej Szczudlik, MD No disclosure on file
Ging-Yuek R. Hsiung, MD, FAAN Dr. Hsiung has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai. Dr. Hsiung has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eli Lilly. The institution of Dr. Hsiung has received research support from CIHR. The institution of Dr. Hsiung has received research support from NIH. The institution of Dr. Hsiung has received research support from Eli Lilly. The institution of Dr. Hsiung has received research support from Biogen.
Antonio Toscano, MD Dr. Toscano has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi Genzyme.
Karen E. Morrison, PhD, FRCP No disclosure on file
Josep Gamez, MD, PhD The institution of Dr. Gamez has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for CSL Behring. The institution of Dr. Gamez has received research support from Government of Spain (FIS FEDER).
Stefania Corti, MD, PhD Dr. Corti has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Corti has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Corti has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sarepta.
Antonio L. Andreu No disclosure on file
Barbara Tomik, MD, PhD No disclosure on file
Don Cleveland, PhD No disclosure on file
Olimpia Musumeci No disclosure on file
Agnieszka Slowik, MD, FAAN Dr. Slowik has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Boehringer, . Dr. Slowik has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Slowik has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis.
Carlo P. Trevisan No disclosure on file
Garth Nicholson, PhD No disclosure on file
Michael Hutton, PhD No disclosure on file
Anna Modoni No disclosure on file
Sergio I. Valdes-Ferrer, MD, PhD No disclosure on file
Agnes Jani-Acsadi, MD No disclosure on file
Najeeb S. Qadi, MD No disclosure on file
Costanza Lamperti No disclosure on file
No disclosure on file
Marc Gotkine, MD No disclosure on file
Christine DiDonato, PhD No disclosure on file
Koji Yamanaka, MD, PhD No disclosure on file
Hanna Rosenmann No disclosure on file
Matthew Greenway, MD No disclosure on file
Roberto Del Bo, PhD No disclosure on file
Lisa Dellefave No disclosure on file
Han-Xiang Deng, MD Dr. Deng has nothing to disclose.
Wuyen Hung No disclosure on file
Dimitra Papadimitriou, DO No disclosure on file
Federica Locatelli, DO No disclosure on file
Bernardo Cacho Diaz, MD, FAAN Dr. Cacho Diaz has nothing to disclose.
Hudson Mesquita No disclosure on file
Denise A. Figlewicz, PhD No disclosure on file
Sumana Gopinath, MD No disclosure on file
Louise R. Simard, PhD No disclosure on file
Gisela Nogales No disclosure on file
Elena Garcia-Arumi No disclosure on file
Jianhua Yan, PhD No disclosure on file
Lijun Wang, MD, PhD No disclosure on file
Suzan Hammond No disclosure on file
Vamshi Rao, MD No disclosure on file
Edoardo Malfatti, MD Dr. Malfatti has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Spark therapeutics. Dr. Malfatti has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sarepta. The institution of Dr. Malfatti has received research support from AFM. The institution of Dr. Malfatti has received research support from Spark Therapeutics.
Xiaoyan Sun, MD, PhD The institution of Dr. Sun has received research support from NIH. The institution of Dr. Sun has received research support from Dr. M. Lee Pearce Foundation.
Shamik Bhattacharyya, MD, FAAN Dr. Bhattacharyya has received personal compensation in the range of $500-$4,999 for serving as a Consultant for NeuroLambda. Dr. Bhattacharyya has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion Pharmaceuticals. Dr. Bhattacharyya has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Amgen. Dr. Bhattacharyya has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Continuum. Dr. Bhattacharyya has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wiley. Dr. Bhattacharyya has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Merck. The institution of Dr. Bhattacharyya has received research support from Alexion Pharmaceuticals. The institution of Dr. Bhattacharyya has received research support from National Institute of Health. The institution of Dr. Bhattacharyya has received research support from UCB. The institution of Dr. Bhattacharyya has received research support from Genentech. Dr. Bhattacharyya has received publishing royalties from a publication relating to health care. Dr. Bhattacharyya has received publishing royalties from a publication relating to health care.
Shilpa Chaku, MD No disclosure on file
Victoria A. Cannon, MD No disclosure on file
Iffat Ara Suchita, MD Dr. Suchita has nothing to disclose.
Nazeem Arsalan, MD No disclosure on file
Madison B. Harris, OT Dr. Harris has nothing to disclose.
Manoj K. Katragadda No disclosure on file
Pascal Lafort No disclosure on file