Abstract Details

Title Experimental Impairment of the Autophagosomal-Lysosomal Pathway (ALP) in Our Cultured Human-Muscle-Fibers Model of s-IBM (IBM-CHMFs Model) Activates [gamma]-Secretase, Resulting in Adversely Increased Production of Amyloid-[beta]42 (A[beta]42) and Its Subsequent Detrimental Oligomerization. Relevance to Sporadic Inclusion-Body Myositis (s-IBM) Pathogenesis

Topic Muscle Disease/Neuromuscular Junction

Presentation(s) (-)

Poster/Presentation
Number 054

Objective

Background

Design/Methods

Results

Conclusions

Authors/Disclosures
Anna Nogalska, PhD	No disclosure on file
Carla D'Agostino, PhD (USC Neuromuscular Center)	No disclosure on file
W. K. Engel, MD, FAAN	No disclosure on file
Valerie Askanas, MD, PhD, FAAN (Professor Emeritus University of Southern California Keck School)	No disclosure on file
Adam Quick, MD (The Ohio State University)	The institution of Dr. Quick has received research support from NINDS. The institution of Dr. Quick has received research support from NEALS.

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