Abstract Details

Title Comparison of Automatic and Manual Transcranial Sonographic Morphometric Measurement of The Substantia Nigra

Topic Clinical Neurophysiology

Presentation(s) S39 - (-)

Poster/Presentation
Number 006

Objective

Background Increased echogenicity of substantia nigra (SN) is a typical transcranial sonography (TCS) finding in Parkinson's disease (PD). The experimental software for quantitative evaluation of echogenic SN area was developed to overcome the main limitation of TCS - the dependency on the sonographer's experience.

Design/Methods Totally 113 healthy volunteers were enrolled to the derivation cohort and 50 healthy volunteers and 30 PD patients to the validation cohort. The SN was imaged from right and left temporal bone window in mesencephalic plane using TCS. All subjects were examined twice using different sonographic machines (My Lab Twice, ESAOTE and Vivid 7 Pro, GE). DICOM images of SN were saved, encoded and processed. Manual and automatic morphologic measurements of SN were performed by experienced sonographer. 90th percentile of derivation cohort values was used as a cut-point for evaluation of hyperechogenic SN in validation cohort. Spearman's coefficient was used for correlation of measurement between manual and automatic measurement. Cohen's kappa coefficient was used for correlation between automatic or manual measurement and PD diagnosis.

Results Spearman's coefficient between measurement using different machines were 0.686 for automatic and 0.721 for manual measurement (P<0.0001for both measurements). Hyperechogenic SN was detected in similar twenty-six (86.7%) PD patients using both automatic and manual measurements. Cohen's kappa coefficient for automatic and manual measurement was 0.787 and 0.762, resp. (P<0.0001 for both measurments).

Conclusions The results of the presented study showed comparable results of SN features measurement using designed application with manual measurement.

Authors/Disclosures
David Skoloudik, MD, PhD (University Hospital Ostrava) PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file

��ɫ��

��ɫ��