Abstract Details

Title Structural and Functional Brain Changes in Boxers and Mixed Martial Arts Fighters Are Correlated with Fight Exposure

Topic Behavioral Neurology

Presentation(s) S54 - (-)

Poster/Presentation
Number 006

Objective

Background Cumulative head trauma can result in chronic traumatic encephalopathy (CTE). The clinical manifestations of CTE include disorders of movement, cognition and behavior. Pathological deposition of tau is found in and around the basal ganglia and cortical mantle in CTE.

Design/Methods The current analysis is cross sectional and involved 155 male fighters participating in the Professional Fighters Brain Health Study. All fighters undergo structural and functional imaging including DTI and a resting state fMRI scans. A group analysis was performed using AFNI and adjusted for age, weight, and education. Number of professional fights and number of reported knock outs were used as surrogate measures of fight exposure.

Results Both greater number of professional fights and number of knock outs were associated with: 1) decreases in transverse diffusivity in the corpus callosum and putamen (p <.005) 2): lower resting state connectivity in the putamen (p <.005).

Conclusions Even early in the fighter's career, we found measurable relationships between structure and function of the basal ganglia and the degree of fight exposure or number of times they were knocked out. We continue the study with longitudinal follow up, and expect to see measurable changes in these structures with increased exposure over time.

Authors/Disclosures
Charles Bernick, MD PRESENTER	Dr. Bernick has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lilly. Dr. Bernick has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Optina. Dr. Bernick has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai. Dr. Bernick has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Corium. Dr. Bernick has stock in Aurora. The institution of Dr. Bernick has received research support from UFC. The institution of Dr. Bernick has received research support from Top Rank Promotions. The institution of Dr. Bernick has received research support from Haymon Boxing.
Christian Krarup, MD, DMSc, FRcP, FAAN (Rigshospitalet)	Dr. Krarup has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Shire/Takeda. Dr. Krarup has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Shire/Takeda. Dr. Krarup has received publishing royalties from a publication relating to health care.
	No disclosure on file
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Michael T. Modic, MD (Cleveland Clinic Foundation)	No disclosure on file

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