Abstract Details

Title White Matter Disease Correlates with Naming Impairment in Semantic Variant Primary Progressive Aphasia

Topic Aging and Dementia

Presentation(s) P06 - (-)

Poster/Presentation
Number 041

Objective

Background BACKGROUND: svPPA is a clinical syndrome most commonly associated with frontotemporal lobar degeneration. svPPA is characterized by deficits in naming as well as single-word and object comprehension resulting in fluent but empty speech. However, little is known about the role of WM disease in naming impairment in svPPA. The Boston Naming Test (BNT) is widely used in clinical assessment of aphasia to evaluate lexical/semantic retrieval. Here we use TSA to relate BNT performance to WM integrity as measured by fractional anisotropy (FA) in svPPA.

Design/Methods DESIGN/METHODS: BNT was collected for 11 patients with svPPA. 30-directional diffusion-weighted images were acquired for these patients and 34 demographically-matched healthy seniors. 11 WM tracts were segmented from a local, aging, DTI template, converted to binary volumes, and modeled as medial surface meshes. For each individual, local maximum FA was computed and projected onto the medial model. This dimensionality reduction increases sensitivity in exchange for a small decrease in local specificity. Permutation-based, cluster-based statistics were used to identify regions of reduced FA in patients with svPPA relative to healthy seniors and areas of correlation between FA and total score on BNT.

Results RESULTS: Areas of reduced FA were present in bilateral inferior fronto-occipital, inferior longitudinal, superior longitudinal, and uncinate fasciculi as well as corpus callosum. Regions of reduced FA were associated with decreased naming performance in bilateral inferior fronto-occipital, bilateral uncinate, corpus callosum, and right inferior longitudinal fasciculi.

Conclusions CONCLUSIONS: TSA revealed significant, widespread WM disease in patients with svPPA, and naming deficits correlated with disease in WM structures related to frontal and temporal neural networks. These findings underline the disruption of a large-scale neural network for naming in svPPA.

Authors/Disclosures
John Powers PRESENTER	No disclosure on file
Corey McMillan, PhD (University of Pennsylvania)	Dr. McMillan has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. The institution of Dr. McMillan has received research support from Biogen. The institution of Dr. McMillan has received research support from NIH.
Gavin Giovannoni, MD (QMUL)	Dr. Giovannoni has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Dr. Giovannoni has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Sanofi. Dr. Giovannoni has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Merck KGaA. Dr. Giovannoni has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Roche-Genentech. Dr. Giovannoni has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Moderna. Dr. Giovannoni has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sandoz. Dr. Giovannoni has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Astoria Biologica. Dr. Giovannoni has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Zenas. Dr. Giovannoni has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Giovannoni has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Giovannoni has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Giovannoni has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Medscape.
	No disclosure on file
	No disclosure on file
	No disclosure on file
Murray Grossman, MD, FAAN (University of Pennsylvania)	Dr. Grossman has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neurology. The institution of Dr. Grossman has received research support from NIH.

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