Abstract Details

Title Examination of the Spinal Cord in Multiple Sclerosis Patients Using Chemical Exchange Saturation Transfer MRI at 7 Tesla

Topic MS and Related Diseases

Presentation(s) P06 - (-)

Poster/Presentation
Number 125

Objective

Background BACKGROUND: Current radiological markers remain insufficient at capturing pathological correlates of multiple sclerosis (MS). Current imaging methods that quantitatively measure tissue properties do not reliably reflect the dynamic and heterogeneous tissue microenvironment present in the pathological white matter. Furthermore, imaging studies typically concentrate on focal lesions. The normal appearing white matter (NAWM) in cervical spinal cord is a largely unexplored area of MS research, particularly at 7 T.

Design/Methods DESIGN/METHODS: All MRI data are acquired on the Philips Achieva 7 T scanner using a surface quadrature coil and 16-channel spine array (Nova Medical) for RF transmission and reception at the level of C2-C4. Statistical analyses are performed in SPSS. Inclusion/Exclusion Criteria: Healthy controls and patients with clinically diagnosed relapsing-remitting MS, based on the McDonald diagnostic criteria above the age of 18 are eligible.

Results RESULTS: CEST imaging of the cervical spinal cord at 7T has reveals differences in the amide proton transfer (APT) metric between healthy white matter and gray matter. Additionally, differences in the APT metric are found in MS lesions of the spinal cord. Further studies focus on normal appearing white matter in the spinal cord with preliminary results indicating the potential to distinguish healthy white matter and normal appearing white matter of MS patients.

Conclusions CONCLUSIONS: CEST MRI at 7T provides increased resolution, signal to noise, and spectral dispersion, facilitating the examination of the biochemical pathyphysiology of MS.

Authors/Disclosures
Adrienne N. Dula, PhD (Dell Medical School) PRESENTER	No disclosure on file
Florian Deisenhammer, MD	Dr. Deisenhammer has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion. Dr. Deisenhammer has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Almirall. Dr. Deisenhammer has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Deisenhammer has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for BMS/Celgene. Dr. Deisenhammer has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi/Genzyme. Dr. Deisenhammer has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Dr. Deisenhammer has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Deisenhammer has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Deisenhammer has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Almirall. Dr. Deisenhammer has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Biogen. Dr. Deisenhammer has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Celgene. Dr. Deisenhammer has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Genzyme. Dr. Deisenhammer has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck. Dr. Deisenhammer has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Novartis. Dr. Deisenhammer has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Dr. Deisenhammer has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for SOBI.
Seth A. Smith, PhD (Vanderbilt University Institute of Imaging Science)	Dr. Smith has nothing to disclose.
	No disclosure on file

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