Abstract Details

Title Neurological Complications in 182 Cases of Primary Sjogren Syndrome

Topic Neurotoxicology

Presentation(s) P06 - (-)

Poster/Presentation
Number 224

Objective

Background BACKGROUND: Primary Sjogren syndrome (PSS) is an autoimmune disease with a wide spectrum of central and peripheral neurological complications. Previous studies have suggested that the antibodies anti-SSA and anti-SSB are associated with neurological complications.

Design/Methods DESIGN/METHODS: Retrospective cohort. We included patients with the diagnosis of PPS according to the criteria of the American College of Rheumatology. We culled the levels of anti-SSA, anti-SSB and RF at the moment of diagnosis of the PPS and we investigated the presence of neurological complications from the onset of the disease to the time of the study.

Results RESULTS: We reviewed the charts of 259 patients and included 182. The number of women was 172 (94.5%) and the mean age was 60 ± 15.35 years. We found 48 patients (26.3%) with a neurological complication that could be attributed to the PPS at some time of the disease. Of these, 44 patients had peripheral nervous system (PNS) complications (24,1%). Only four patients (2.18%) had CNS complications. Three had longitudinal myelitis and one supratentorial demyelination, The PNS complications were distal sensory-motor peripheral neuropathy in 16 (8.79%), entrapment neuropathy in 15 (8.24%), small fiber painful neuropathy in 7 (4%), hypokalemic periodic paralysis in 2 (1%), cranial neuropathy, and mononeuritis multiplex in 2 (1%). Antibodies were available in 134 cases without neurological impairment and in 48 of the affected cases. The levels of antibodies were not significantly different between the patients with and without neurological complications.

Conclusions CONCLUSIONS: We did not find a significant difference in antibodies between the patients with and without neurological complications. Although small fiber neuropathy is a well recognized form of peripheral neuropathy in PPS the most common neuropathy was distal sensory-motor neuropathy.

Authors/Disclosures
PRESENTER	No disclosure on file
Zaira Medina, MD (Private)	No disclosure on file
	No disclosure on file
Bruno E. Vidal, MD (Instituto Nacional de Ciencias Médicas y Nutrición)	No disclosure on file
Gerald Raymond, MD (Johns Hopkins)	Dr. Raymond has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Bluebird bio. Dr. Raymond has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Ionis. Dr. Raymond has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Travere. Dr. Raymond has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant with Dept of HHS.
Harald Hegen, MD	Dr. Hegen has nothing to disclose.

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