Abstract Details

Title [18F] Flutemetamol Amyloid-beta Imaging across the Spectrum of Alzheimer's Disease

Topic Aging and Dementia

Presentation(s) P06 - (-)

Poster/Presentation
Number 038

Objective

Background BACKGROUND: The PET amyloid imaging with [18F]-labeled PIB derivate [18F]-Flutemetamol have recently developed to be a new novel technology of underlying AD pathology.

Design/Methods DESIGN/METHODS: Thirteen patients with AD, 31 with mild cognitive impairment (MCI) and 19 subjects with healthy control (HC) were studied. All 63 patients underwent 30-min static [18F]-FMM PET, acquired 85 min after injection (193.5 ± 6.6 MBq), and 60-min dynamic [11C]-PIB PET. [18F]-FMM scans were assessed visually by 3 individuals as abnormal or normal cortical uptake, and the standardized uptake value ratios (SUVR) were defined quantitatively in regions of interest defined on co-registered MRI (cerebellar gray as a reference region). The PIB distribution volume ratios (DVR) were determined in same cortical regions.

Results RESULTS: The visual assessments of [18F]-FMM scans had an increased A? deposition in all of 13 scans with AD patients and 1 of 19 scans with HC subjects, corresponding to a sensitivity of 96.2% and a specificity of 93.3%. These findings were completely same to [11C]-PIB scans. The [18F] SUVR value in whole cortical regions in AD was significantly greater than in 18F]-FMM negative HC (1.81 ± 0.22 vs 1.24 ± 0.09, P<0.01). MCI patients had a bimodal distribution of SUVRs. The SUVRs in 6 patients with [18F]-FMM positive MCI and 25 patients with negative MCI were 1.87 ± 0.27 and 1.19 ± 0.08, respectively. The [18F]-FMM SUVR values in all individual subjects were significantly correlated with [11C] PIB DVR values (r=0.94, n=63, p<0.001).

Conclusions CONCLUSIONS: [18F] Flutemetamol PET provides images similar to [11C]-PIB PET, and is a reliable imaging biomarker of A? deposition along the continuum from normal cognitive status to AD dementia.

Authors/Disclosures
Shizuo Hatashita, MD, PhD PRESENTER	No disclosure on file
Mitchell Silver, MD (Kennedy Medical Group)	Dr. Silver has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file

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