Abstract Details

Title White Matter Microstructure and Cognitive Dysfunction in Systemic Lupus Patients

Topic Neurotoxicology

Presentation(s) P06 - (-)

Poster/Presentation
Number 204

Objective

Background BACKGROUND: Approximately 60% of persons diagnosed with Systemic lupus erythematosus experience neurological complications at some time in the course of their disease. The most common of these neurological complications is neurocognitive abnormality.

Design/Methods DESIGN/METHODS: Twenty eight systemic lupus patients and twenty sex and age matched healthy controls were included in this study. For the both patient and control groups brain magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS) and cognitive function- assessed by Mini-Mental State Examination (MMSE)- were performed. White matter structural and metabolic measures were analyzed and correlated with cognitive function and systemic lupus erythematosus disease activity index.

Results RESULTS: No significant differences found in the total brain grey and white matter volumes or in frontal white matter Nacetyl aspartate/creatine (NAA/Cre) and N-acetyl aspartate/choline (NAA/Cho) between patient and control groups. Patients had significant increase Choline/Creatine (Cho/Cre) in frontal white matter. About 57.1% of SLE patients had cognitive impairment that was correlated to higher frontal white matter Cho/Cre but not to SLE disease activity index.

Conclusions CONCLUSIONS: SLE patients had frontal white matter metabolic changes that correlated with cognitive impairment, whereas no cerebral atrophy or white matter axonal damage was evident.

Authors/Disclosures
Mohammad Abu-Hegazy, MD, PhD, FAAN (Mansaoura Faculty of Medicine) PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
Zhixiao Wang, PhD (Eisai Inc)	No disclosure on file

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