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Abstract Details

Comparing White Matter Tracts of Patients with Relapsing-Remitting Multiple Sclerosis, Systemic Lupus Erythematosus and Healthy Controls Using Tract-Based Spatial Statistics (TBSS)
Neurotoxicology
P06 - (-)
196
BACKGROUND: MS and SLE are central nervous system (CNS) diseases of autoimmune origin. Patients of both diseases present with neuropsychological impairment and formation of lesions and development of brain atrophy. The inherent differences in WM integrity of patients with these diseases compared to healthy controls are not understood.
DESIGN/METHODS: The studied groups consisted of 30 relapsing-remitting MS patients (mean age of 43.8 卤8.4 and a mean disease duration of 12.1 卤7.9), 32 patients with SLE (mean age of 48.1 卤12.4 with a mean disease duration of 14.38 卤8.6) and 43 healthy controls (mean age of 44.7 卤9.8). DTI was performed on a 3T scanner in all patients and controls. The DTI images were post-processed using the FSL Software Package (Oxford, UK) and also Advanced Normalization Tools (ANTS) to correct for lesions. The images were then analyzed using a TBSS analysis. FSL's randomize tool was used to perform permutation-based statistical inference. WM tract integrity was determined among the groups by comparing mean fractional anisotropy (FA).
RESULTS: SLE patients and MS patients had decreased FA in subcortical areas compared to healthy controls (p<.001 Decreased FA was detected in MS compared to SLE patients in subcortical areas including the corpus callosum, thalamus, and fornix (p<.001).
CONCLUSIONS: This study shows that SLE and MS patients have microscopic damage to WM fiber structure compared with healthy controls. MS patients, however, have greater microscopic WM damage in the areas of high axonal traffic, like the thalamus and corpus callosum, compared to SLE patients.
Authors/Disclosures
Brittany Cesar
PRESENTER 		No disclosure on file
Janet L. Shucard, PhD (Buffalo General Hospital) The institution of an immediate family member of Dr. Shucard has received research support from Department of Defense.
Michael G. Dwyer III, MD, PhD (Buffalo Neurological Analysis Center) Dr. Dwyer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Dwyer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Keystone Heart, Ltd. Dr. Dwyer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novartis. The institution of Dr. Dwyer has received research support from Novartis. The institution of Dr. Dwyer has received research support from Keystone Heart, Ltd. The institution of Dr. Dwyer has received research support from Bristol Myers Squibb. The institution of Dr. Dwyer has received research support from Roche.
No disclosure on file
Niels Bergsland (Buffalo Neuroimaging Analysis Center / State University of New York At Buffalo) Prof. Bergsland has nothing to disclose.
Alex Rovira Alex Rovira has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofy. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer. Alex Rovira has stock in Tensor Medical.
Ralph H. Benedict, PhD (University At Buffalo) Dr. Benedict has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Roche. Dr. Benedict has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. Dr. Benedict has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Bristol Meyers Squibb. Dr. Benedict has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Immunic Therapeutics. Dr. Benedict has received intellectual property interests from a discovery or technology relating to health care.
David W. Shucard, PhD (State Univ of NY At Buffalo School of Medicine) The institution of Dr. Shucard has received research support from Dept of Defense.
Robert Zivadinov, MD, PhD, FAAN (Buffalo Neuroimaging Analysis Center) The institution of Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BMS. The institution of Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Omnicuris. The institution of Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Myrobalan. Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Zivadinov has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for EMD Serono. Dr. Zivadinov has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Bristol Myers Squibb. The institution of Dr. Zivadinov has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen.