Abstract Details

Title Brain Atrophy in Radiologically Isolated Syndromes

Topic MS and Related Diseases

Presentation(s) P06 - (-)

Poster/Presentation
Number 117

Objective

Background BACKGROUND: MRI lesions suggestive of multiple sclerosis (MS) in the absence of a clinical scenario is a condition named ''radiologically isolated syndrome'' (RIS). Scarce data exists about brain atrophy this condition.

Design/Methods DESIGN/METHODS: patients with RIS were included prospectively during June 2009 to June 2012. CIS patients (with less than a year of disease onset) and healthy volunteers matched by age and gender and included during the same period of time were used as control groups. An automated analysis tool, SIENAX, was used to obtain total brain volume (TBV), gray matter volume (GMV) and white matter volume (WMV). K-Wallis test was used to analyze the data.

Results RESULTS: 12 RIS patients, 43 CIS patients and 29 healthy controls were included. Mean age for RIS was 30 ± 5.4 years vs. 34± 7 in CIS patients and 34.4 ± 9 in healthy controls (p=0.29). The TBV in RIS was 1.53 mm3 x 106, 1.51 x 106 in CIS and 1.64 x 106 in healthy controls (p= 0.12 vs. CIS and p=0.003 vs. healthy controls); the GMV in RIS was 0.56 x 106, 0.53 x 106 in CIS and 0.71 x 106 in healthy controls (p=0.2 vs. CIS and p=0.003 vs. healthy controls) and the WMV in RIS was 1 x 106, 0.98 in CIS and 1.12 x 106 in healthy controls (p=0.66 vs. CIS and p=0.12 vs. healthy controls).

Conclusions CONCLUSIONS: our study showed a decrease in brain volume of RIS patients compared with healthy controls similar to CIS patients. Future studies will help to confirm this finding.

Authors/Disclosures
PRESENTER	No disclosure on file
Timothy L. Vollmer, MD, FAAN	The institution of Dr. Vollmer has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen IDEC. The institution of Dr. Vollmer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Genentech/Roche. The institution of Dr. Vollmer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Siranax. The institution of Dr. Vollmer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Celgene. The institution of Dr. Vollmer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EMD Serono. The institution of Dr. Vollmer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Meyers Squib. The institution of Dr. Vollmer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Viela Bios. The institution of Dr. Vollmer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. The institution of Dr. Vollmer has received research support from Rocky Mountain MS Center. The institution of Dr. Vollmer has received research support from Biogen. The institution of Dr. Vollmer has received research support from Actelion. The institution of Dr. Vollmer has received research support from Genentech/Roche. The institution of Dr. Vollmer has received research support from Anokion. The institution of Dr. Vollmer has received research support from TG Therapeutics.
Liliana B. Patrucco, MD (Hospital Italiano De Buenos Aires)	Dr. Patrucco has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck. Dr. Patrucco has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Dr. Patrucco has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Novartis. Dr. Patrucco has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Biogen.
Edgardo Cristiano, MD (Hospital Italiano De Buenos Aires)	Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Genzyme. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Dr. Cristiano has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck.
Kenny S. Frazier	No disclosure on file

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