Abstract Details

Title Enhanced or Decreased Female Sexual Function Depends on Location and Volume of Multiple Sclerosis Lesions

Topic MS and Related Diseases

Presentation(s) P06 - (-)

Poster/Presentation
Number 111

Objective

Background BACKGROUND: Neuroimaging identified brain areas involved in sexual function. In women with Multiple Sclerosis (MS); associations between sexual function and the site and size of MS-related magnetic resonance imaging (MRI) changes are undetermined.

Design/Methods DESIGN/METHODS: In 50 female MS-patients (37.0±9.9 years), we assessed scores of the 19-item Female Sexual Function Index (FSFI) evaluating desire, arousal, lubrication, orgasm, satisfaction, pain (Rosen et al. J Sex Marital Ther. 2000;26:191-208), and determined cerebral and spinal MS-lesion-load and -location in T2-weighed 1.5T MRIs. We correlated FSFI-scores with MS-lesion-load in frontal, parietal, temporal, occipital, opercular, cingulate, thalamic, midbrain, cerebellar, pontine, medulla oblongata, and spinal cord areas, using the Spearman-rank correlation coefficient (significance: p<0.05).

Results RESULTS: FSFI-desire-scores correlated directly with left frontal-premotor and thalamic lesion-volumes. FSFI-arousal-scores correlated directly with right frontal primary-motor cortex and midbrain lesion-volumes. FSFI-lubrication-scores correlated inversely with right occipital middle/inferior gyral lesion-volumes, but directly with right prefrontal/orbitofrontal cortex, temporal middle/inferior gyrus cortical, temporal peri-amygdaloid, midbrain lesion-volumes and left pontine lesion-volumes. FSFI-orgasm-scores correlated inversely with left temporal periventricular, and right middle/inferior occipital lesion-volumes, but directly with right frontal primary motor cortex, temporal peri-amygdaloid, left temporal middle/inferior gyral, and midbrain lesion-volumes. FSFI-satisfaction-scores correlated inversely with occipital and directly with right frontal primary-motor lesion-volumes. FSFI-pain-scores correlated directly with right prefrontal/orbitofrontal, primary-motor, temporal peri-amygdaloid, parietal-cortical lesion-volumes and left temporal middle/inferior gyral lesion-volumes.

Conclusions CONCLUSIONS: Surprisingly, FSFI-scores for desire, arousal, lubrication, orgasm, satisfaction but also pain showed direct correlations with MS lesion-loads in multiple brain areas, suggesting associations between enhanced sexual function - but also pain - and MS-lesions in these areas. In contrast, lesions in the right occipital and left temporal periventricular region deteriorate lubrication, orgasmic function, and satisfaction.

Authors/Disclosures
Klemens Winder, MD PRESENTER	No disclosure on file
Julia Koehn, MD (University of Erlangen-Nuremberg)	No disclosure on file
David S. Knopman, MD, FAAN (Mayo Clinic)	Dr. Knopman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for DIAN TU study. The institution of Dr. Knopman has received research support from NIH.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Max J. Hilz, MD, PhD, FAAN	Dr. Hilz has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for SANOFI. Dr. Hilz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Pfizer. Dr. Hilz has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier.
Gene Y. Sung, MD, MPH (U.S.C. Neurology)	The institution of Dr. Sung has received research support from NIH.

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