Abstract Details

Title Surface Expansion of the Hippocampal Dentate Gyrus in Multiple Aclerosis: An In-Vivo Evidence of Neurogenesis?

Topic MS and Related Diseases

Presentation(s) P06 - (-)

Poster/Presentation
Number 127

Objective

Background BACKGROUND: Inflammatory responses within the CNS have the potential to alter the homeostasis of the staminal niche and enhance neurogenesis in the subgranular zone of the dentate gyrus. The functional significance of adult neurogenesis in CNS pathology is still under debate.

Design/Methods DESIGN/METHODS: Brain 3D T1-weighted scans were acquired from 115 MS patients (28 relapsing remitting [RR], 34 secondary progressive [SP], 27 primary progressive [PP], 26 benign [B] MS) and 28 healthy controls (HC). Hippocampal segmentation was performed manually according to standardized procedures. From contours, radial distances were calculated and between-group vertex analysis performed (independent sample t-test, age adjusted). Percentage difference of average medial distance (AMD) in clusters of significant difference (p < 0.05) was calculated.

Results RESULTS: When compared to HC, all MS phenotypes revealed an increase AMD in correspondence to the dentate gyrus, bilaterally. The percentage change of AMD and the cluster dimensions (number of vertices) were for RRMS vs. HC: right hippocampus +23.5%, 61; left hippocampus +26.9%, 275, for SPMS vs. HC: right hippocampus +23%, 21; left hippocampus +17.7%, 470, for PPMS vs. HC: right hippocampus +11.1%, 192; left hippocampus +16.1%, 268, and for BMS vs. HC: right hippocampus n.s.; left hippocampus +17.9%, 57.

Conclusions CONCLUSIONS: Surface expansion of the dentate gyrus of the hippocampi might represent an inflammation-induced alteration of the neurogenic niche in the adult subgranular zone. This seems to be strengthened by the pronounced effect found in the early and most inflammatory phases of the disease. If confirmed, this finding could provide a tool for monitoring the neuroprotective effects of immunomodulatory treatments.

Authors/Disclosures
Giulia Longoni, MD (The Hospital for Sick Children) PRESENTER	Dr. Longoni has nothing to disclose.
Maria A. Rocca (Neuroimaging Research Unit)	Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen, Bristol Myers Squibb, Eli Lilly, Janssen, Roche. Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AstraZaneca, Biogen, Bristol Myers Squibb, Bromatech, Celgene, Genzyme, Horizon Therapeutics Italy, Merck Serono SpA, Novartis, Roche, Sanofi and Teva. The institution of Maria Assunta Rocca has received research support from MS Society of Canada, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.
Elisabetta Pagani	Elisabetta Pagani has nothing to disclose.
Gianna Carla Riccitelli (San Raffaele)	No disclosure on file
	No disclosure on file
	No disclosure on file
Andrea Falini	No disclosure on file
Giancarlo Comi, MD (University Vita-Salute)	Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Aspen Healthcare. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Rewind.
Michael W. Weiner, MD	Dr. Weiner has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Dolby Family Ventures. Dr. Weiner has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Acadia Pharmaceuicals. Dr. Weiner has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Acumen Pharmaceuticals. Dr. Weiner has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Guidepoibnt. Dr. Weiner has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Owkin France. Dr. Weiner has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Quantum Leap Health. Dr. Weiner has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sai MedPartners. Dr. Weiner has received personal compensation in the range of $500-$4,999 for serving as a Consultant for MEDA Corp.. Dr. Weiner has stock in Anven. Dr. Weiner has stock in Alzeca. Dr. Weiner has stock in Alzheon, Inc.. Dr. Weiner has stock in ALZpath. The institution of Dr. Weiner has received research support from NIH/NIA; National Institutes of Health/National Institutes of Aging. Dr. Weiner has received personal compensation in the range of $500-$4,999 for serving as a Speaker/Presenter with Merck Sharp & Dohme. Dr. Weiner has received personal compensation in the range of $0-$499 for serving as a Speaker/Presenter with BrightFocus Foundation. Dr. Weiner has received personal compensation in the range of $500-$4,999 for serving as a Speaker/Presenter with Banner Health.
Massimo Filippi, MD, FAAN (Ospedale San Raffaele, Neuroimaging Research Unit)	Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.

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