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Abstract Details

Increasing Efficiency of Intracranial Cavity Determination from High-Resolution 3 Tesla(T) MRI Scans of the Brain
MS and Related Diseases
P06 - (-)
121
BACKGROUND: Accurate ICC segmentation is a critical step in image analysis, e.g. cerebral atrophy measurement in Multiple Sclerosis (MS). The ongoing switch from 1.5T to 3T scanners substantially increases the data-volume per scan and hence effort required for manual correction. Manual editing is imperative for robust morphometry, but effort is rapidly becoming prohibitive.
DESIGN/METHODS: 3T brain MRI scans were obtained at 1mm isotropic resolution (30 subjects, 10 each from MS, normal aging, gait impairment). ICCs were segmented using automated freely available softwares, and best outputs were chosen for manual editing. Subsampled (2-10-fold) output versions were generated for testing, then restored to original resolution with custom algorithm combining iterative Gaussian smoothing and upsampling. Accuracy was assessed by comparing manual edits of subsampled versions with manual gold-standards created at original resolution. Optimal reduction orientation and ratios were determined by measuring accuracy loss through subsampling the gold-standard, assessed as Dice overlap coefficient, sensitivity, specificity and positive predictive value (PPV).
RESULTS: Segmentation results could be safely reduced from 1mm to 3mm axial for manual editing without significant accuracy loss [(mean卤 SD) sensitivity= 0.9895卤0.0060, specificity=0.9978卤0.0005, PPV=0.9874卤0.0029, dice=0.9885卤0.0023]. Automated 2mm-10mm subsampling showed no significant accuracy loss for up to 5mm-subsampling, with best-accuracy at 3mm-subsampling. Accuracy declined for subsampling beyond the 5mm-level. Axial orientation proved most reliable.
CONCLUSIONS: Even after threefold subsampling , the same level of robustness in ICC segmentation can be achieved as with 1mm isotropic brain images. This is pertinent for large centers and high volumes of scans, where reducing manual editing time is critical. Furthermore these studies set the stage for further investigations regarding the feasibility of performing high throughput routine processing of 3T brain images to obtain quantitative data in diseases such as MS.
Authors/Disclosures
Ashish Arora, MD (The Moses H Cone Memorial Hospital)
PRESENTER 		No disclosure on file
Nicola Moscufo (Brigham & Women's Hospital) No disclosure on file
Mohit Neema, MD No disclosure on file
Howard L. Weiner, MD (Brigham and Women'S Hospital) Dr. Weiner has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Weiner has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Medday Pharmaceuticals. Dr. Weiner has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for vTv Therapeutics. Dr. Weiner has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Tiziana Life Sciences. Dr. Weiner has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for vTv Therapeutics. Dr. Weiner has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Medday Pharmaceuticals. Dr. Weiner has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for vTv Therapeutics. Dr. Weiner has stock in vTv Therapeutics. The institution of Dr. Weiner has received research support from National Institute of Health. The institution of Dr. Weiner has received research support from National MS Society. The institution of Dr. Weiner has received research support from Genzyme Corp. The institution of Dr. Weiner has received research support from Genentech, Inc. . The institution of Dr. Weiner has received research support from Verily Life Sciences LLC. The institution of Dr. Weiner has received research support from EMD Serono, Inc..
Charles R. Guttmann Charles R.G. Guttmann has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sintetica SA. Charles R.G. Guttmann has received stock or an ownership interest from Alnylam. Charles R.G. Guttmann has received stock or an ownership interest from Roche. Charles R.G. Guttmann has received stock or an ownership interest from Novartis. Charles R.G. Guttmann has received stock or an ownership interest from Arrowhead Pharmaceuticals. Charles R.G. Guttmann has received stock or an ownership interest from Protalix. Charles R.G. Guttmann has received stock or an ownership interest from Promethee. Charles R.G. Guttmann has received stock or an ownership interest from GSK. Charles R.G. Guttmann has received stock or an ownership interest from Sangamo. Charles R.G. Guttmann has received stock or an ownership interest from Alcon. Charles R.G. Guttmann has received stock or an ownership interest from Cocrystal Pharma. The institution of Charles R.G. Guttmann has received research support from NIH. The institution of Charles R.G. Guttmann has received research support from McGill University. The institution of Charles R.G. Guttmann has received research support from National Multiple Sclerosis Society. The institution of Charles R.G. Guttmann has received research support from BrightFocus Foundation. The institution of Charles R.G. Guttmann has received research support from National Multiple Sclerosis Society. The institution of Charles R.G. Guttmann has received research support from University of Connecticut Health Center. The institution of Charles R.G. Guttmann has received research support from U.S. Office of Naval Research.
Rohit Bakshi, MD, FAAN Dr. Bakshi has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for EMD Serono. Dr. Bakshi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. The institution of Dr. Bakshi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Journal of Neuroimaging. The institution of Dr. Bakshi has received research support from Bristol Myers Squibb. The institution of Dr. Bakshi has received research support from EMD Serono. The institution of Dr. Bakshi has received research support from Novartis.
Dominik S. Meier, PhD (Brigham & Women's Hospital) No disclosure on file
Allan G. Kermode, MD, MBBS, FRACP (SJOG Clinic, Suite 314) Dr. Kermode has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Kermode has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Roche.