Abstract Details

Title Investigating the Role of the Interleukin-1 Gene System Polymorphism in Psychiatric Migraine Comorbidity

Topic Headache

Presentation(s) P06 - (-)

Poster/Presentation
Number 153

Objective

Background BACKGROUND: Several studies showed a significant link between migraine and psychiatric disturbances. Pro-inflammatory cytokines have been shown to influence the psychopathological symptoms in depressive and anxiety disorders. Interleukin-1 system includes 11 proteins codified by 11 different genes. Interleukin-1? (IL-1?), interleukin-1? (IL-1?) and the receptor antagonist (IL-RA) are pleiotropic cytokines influencing several physiologic functions. Recent studies showed a relevant role for IL-1? gene in the pathogenesis of major depression.

Design/Methods DESIGN/METHODS: 267 patients (191 females and 76 males) referring to the Headache Centre, University of Torino, were enrolled in the study. Migraine diagnosis was made according to ICDH II Criteria. Patients underwent clinical and neurological examination, and neuropsychological evaluation with Beck Depression Inventory (BDI), STAI-X1 and STAI-X2. Genomic DNA was extracted. All patients were genotyped for the functionally active polymorphisms of IL-1: IL-1? -889 C>T, IL-1? -511 C>T, IL-1? +3953 C>T, IL-1RA VNTR. Statistical analysis was conducted using SPSS 18.

Results RESULTS: Migraineurs homozygous for the C allele of the IL-1?-511 polymorphism, associated to higher plasmatic concentrations of cytokine, presented higher scores in BDI (p=0.04), STAI-X1 (p=0.04), STAI-X2 (p=0.03) tests, when compared to remaining genotypes. The polymorphisms IL1? -889 C>T, IL1? +3953 C>T and IL1RA VNTR were not found significantly correlated to the different psychological tests.

Conclusions CONCLUSIONS: Migraine patients carrying the functionally active polymorphism -511 of the IL-1? gene present higher scores in anxiety and depression scales. To our knowledge, this is the first study investigating the role of pro-inflammatory cytokines in psychiatric symptoms of migraine, therefore our results must be critically examined. Our preliminary results suggest a role for IL-1? gene in psychopathological symptoms of migraine patients. Further studies are needed to better define the biological role of proinflammatory cytokines in psychiatric comorbidity of migraine.

Authors/Disclosures
Paola De Martino, MD, PhD PRESENTER	No disclosure on file
Oron Yacobi-Zeevi	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Lorenzo Pinessi, MD (University of Turin/Dept of Neuroscience)	No disclosure on file
Innocenzo Rainero, MD, PhD (University of Turin)	No disclosure on file

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