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Abstract Details

Disruption of Structural Connectivity along the Dorsal and Ventral Language Pathways in Patients with Nonfluent and Semantic Variant Primary Progressive Aphasia
Behavioral Neurology
P06 - (-)
070
BACKGROUND: NFV and SV variants of PPA are associated with distinct patterns of focal cortical atrophy and underlying pathology. Current theories on brain organization suggest that cognitive functions, such as language, are organized as distributed, segregated, and overlapped networks. Anatomically, such large-scale networks comprise specialized brain cortical areas and their interconnecting WM fiber tracts.
DESIGN/METHODS: Thirteen NFV patients, 13 SV patients, and 35 age- and sex-matched healthy subjects underwent structural and DT MRI scans. Probabilistic tractography was used to track inferior longitudinal, superior longitudinal, and uncinate, bilaterally, as well as corpus callosum. Tractography was then combined with tract-based spatial statistics to perform a voxel-wise analysis of fractional anisotropy, axial, radial and mean diffusivities, within skeletonized tract masks.
RESULTS: Despite we found that the two PPA variants share a common pattern of dorsal and ventral pathway abnormalities, significant differences in the distribution of the microstructural damage of the major language pathways were also detected, with NFV patients having a more severe damage to the dorsal (fronto-parietal) WM connections within the left superior longitudinal fasciculus/arcuate and SV patients experiencing a greater left ventral tract involvement (inferior longitudinal and uncinate fasciculi).
CONCLUSIONS: These findings offer direct evidence that dorsal and ventral language networks contribute to the relatively selective deficits in NFV and SV patients.
Authors/Disclosures

PRESENTER 		No disclosure on file
Federica Agosta (San Raffaele Scientific Institute) Federica Agosta has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philips. Federica Agosta has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier INC.
Elisa Canu (Ospedale San Raffaele) The institution of Elisa Canu has received research support from Italian Ministry of Health .
Stefano F. Cappa, MD Dr. Cappa has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elservier. The institution of Dr. Cappa has received research support from Italian Minsitry of Health.
Giuseppe Magnani Giuseppe Magnani has nothing to disclose.
Massimo Franceschi, MD No disclosure on file
Andrea Falini No disclosure on file
Giancarlo Comi, MD (University Vita-Salute) Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Aspen Healthcare. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Sanofi. Dr. Comi has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Rewind.
Massimo Filippi, MD, FAAN (Ospedale San Raffaele, Neuroimaging Research Unit) Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.
David S. Knopman, MD, FAAN (Mayo Clinic) Dr. Knopman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for DIAN TU study. The institution of Dr. Knopman has received research support from NIH.