Abstract Details

Title The Longitudinal Relationship between Deep Gray Matter Atrophy and White Matter Tract Damage in Multiple Sclerosis: A 3T MRI Study

Topic MS and Related Diseases

Presentation(s) P06 - (-)

Poster/Presentation
Number 119

Objective

Background BACKGROUND: Cross-sectional MRI studies suggest a link between WM tract damage and DGM atrophy, however their longitudinal relationship is still unclear in MS.

Design/Methods DESIGN/METHODS: We studied 25 MS patients and 9 normal controls (NC) over a 1.2±0.4 year follow-up using 3T MRI. Baseline and follow-up DGM volumes and diffusion tensor imaging (DTI) derived core fractional anisotropy (FA) of major WM tracts were assessed using FSL-FIRST software and FSL tract-based spatial statistics respectively. Linear modeling assessed MS vs. NC differences in DGM volumes and FA values in WM tracts at baseline and longitudinally. In the MS group, regression modeling tested the ability of baseline DGM volumes to predict FA changes in WM tracts.

Results RESULTS: At baseline, compared to NC, MS patients showed left thalamic atrophy (p=0.045), a trend towards right thalamic atrophy (p=0.057) and lower FA in several WM tracts (corona radiata, left posterior thalamic radiation, left external capsule, and left superior longitudinal fasciculus; all p<0.05). On-study decreasing FA values were seen in MS vs. NC in the corpus callosum, right internal capsule, and left sagittal striatum (all p<0.04), while no DGM volume changes were observed. In the MS group, right thalamic volume at baseline was associated with on-study lower FA in the corpus callosum (p=0.04).

Conclusions CONCLUSIONS: These data show the sensitivity of DTI to ongoing WM tract damage over one-year. Furthermore, these results show a link between DGM atrophy and WM tract damage. Further larger studies that include cortical areas in the modeling of the link between GM atrophy and WM damage would be of interest to extend these findings.

Authors/Disclosures
Mohit Neema, MD PRESENTER	No disclosure on file
Ashish Arora, MD (The Moses H Cone Memorial Hospital)	No disclosure on file
Rohit Bakshi, MD, FAAN	Dr. Bakshi has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for EMD Serono. Dr. Bakshi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. The institution of Dr. Bakshi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Journal of Neuroimaging. The institution of Dr. Bakshi has received research support from Bristol Myers Squibb. The institution of Dr. Bakshi has received research support from EMD Serono. The institution of Dr. Bakshi has received research support from Novartis.
Antonia Ceccarelli, MD, PhD (Epicura Centre Hospitalier, VUB)	No disclosure on file
	No disclosure on file

��ɫ��

��ɫ��